1 Overview

Data

Normalization

Model options

Network processing

cor/cov method: pearson

2 Load and normalize data

Data

Normalization

2.1 Load TCGA data

See prepare.tcga.survival.data function for how to configure parameters.

This uses data packages from obtained from ‘github:averissimo/tcga’ that contain FPKM expression levels.

prepare.tcga.survival.data('lgg.data.2018.10.17',
                           'primary.solid.tumor',
                            normalization        = 'center',
                            log2.pre.normalize   = TRUE,
                            handle.duplicates    = 'keep_first',
                            coding.genes         = TRUE,
                            subtract.surv.column = '')

2.1.1 Summary of data

## [INFO]        Loaded data from TCGA: lgg.data.2018.10.17
## [INFO]               type of tissue: primary.solid.tumor
## [INFO]   observations (individuals): 488 (123 event / 365 censored)
## [INFO]            variables (genes): 19848

2.1.2 Survival curve

2.2 Load degree data

Network processing

  • Degree calculation: string
  • Edge cutoff: 0
  • Unweighted edges

cor/cov method: pearson

  • only applies if network type is correlation/covariance

2.3 Preparing degree vector

  • Normalize degree between 0 and 1
  • Hub: heuristic( 1 - degree )
  • Orphan: heuristic( degree )
  • trans.fun is a double power to scale the values

see ?glmSparseNet::heuristicScale or ?glmSparseNet::hubHeuristic

# see ?glmSparseNet::heuristic.scale
trans.fun <- function(x) {
    heuristicScale(x) + 0.2
}

2.3.1 Genes with degree above 4000

ensembl_gene_id degree external_gene_name
ENSG00000150991 10394 UBC
ENSG00000170325 6346 PRDM10
ENSG00000100300 5797 TSPO
ENSG00000174775 5614 HRAS
ENSG00000142208 5573 AKT1
ENSG00000111640 5363 GAPDH
ENSG00000163631 5260 ALB
ENSG00000177606 4952 JUN
ENSG00000141510 4936 TP53
ENSG00000197122 4903 SRC
ENSG00000254647 4592 INS
ENSG00000112062 4187 MAPK14
ENSG00000170315 4114 UBB
ENSG00000170345 4010 FOS

2.3.2 Original degree frequency

Original

LOG10 Scale on X-axis

3 Model Inference

3.1 Train and test sets

## [INFO] Size of sets: (size/events)
##  * Train: 80.00% ::  390 /   98
##  *  Test: 20.00% ::   98 /  25
## [INFO] Number of variables per model:
Model BaseModel Alpha TargetVars nvars
Elastic Net Elastic Net 0.10 175 177
Hub Elastic Net 0.10 175 179
Orphan Elastic Net 0.10 175 177
Elastic Net Hub 0.20 51 51
Hub Hub 0.20 51 52
Orphan Hub 0.20 51 51
Elastic Net Orphan 0.20 101 101
Hub Orphan 0.20 101 101
Orphan Orphan 0.20 101 103 
## [INFO] note, selected variables could be slightly different from target, to have more accuracy increase nlambda in code

4 Results

4.1 Relative risk distribution

Calculated using the inferred models and the train/test datasets. The higher the better.

Test Set

Train Set

4.2 Kaplan-Meier Curves

4.2.1 Models on test sets

Elastic Net (base model: Elastic Net)

Test set

Training set

Hub (base model: Elastic Net)

Test set

Training set

Orphan (base model: Elastic Net)

Test set

Training set

Elastic Net (base model: Hub)

Test set

Training set

Hub (base model: Hub)

Test set

Training set

Orphan (base model: Hub)

Test set

Training set

Elastic Net (base model: Orphan)

Test set

Training set

Hub (base model: Orphan)

Test set

Training set

Orphan (base model: Orphan)

Test set

Training set

4.3 Summary Table

weighted penalization project tissue cutoff coding.genes alpha model nvars km.train km.test c.index.train c.index.test
FALSE string lgg.data.2018.10.17 primary.solid.tumor 0 TRUE 0.10 Elastic Net 177 0 0.0009926 0.9072907 0.7828887
FALSE string lgg.data.2018.10.17 primary.solid.tumor 0 TRUE 0.10 Hub 179 0 0.0006412 0.9359539 0.7902484
FALSE string lgg.data.2018.10.17 primary.solid.tumor 0 TRUE 0.10 Orphan 177 0 0.0006837 0.9102640 0.7709292
FALSE string lgg.data.2018.10.17 primary.solid.tumor 0 TRUE 0.20 Elastic Net 51 0 0.0205721 0.8735728 0.7571297
FALSE string lgg.data.2018.10.17 primary.solid.tumor 0 TRUE 0.20 Hub 52 0 0.0021967 0.8655447 0.7792088
FALSE string lgg.data.2018.10.17 primary.solid.tumor 0 TRUE 0.20 Orphan 51 0 0.0072572 0.8739891 0.7516099
FALSE string lgg.data.2018.10.17 primary.solid.tumor 0 TRUE 0.20 Elastic Net 101 0 0.0011136 0.9082422 0.7838086
FALSE string lgg.data.2018.10.17 primary.solid.tumor 0 TRUE 0.20 Hub 101 0 0.0014091 0.9236441 0.7847286
FALSE string lgg.data.2018.10.17 primary.solid.tumor 0 TRUE 0.20 Orphan 103 0 0.0030161 0.9066960 0.7700092

4.4 Non-zero genes

4.4.1 Venn Diagram of selected genes

4.4.1.1 Overlap between models (with same target number of variables)

Base model: Elastic Net with Target Vars: 175 and Alpha: 0.10

Base model: Hub with Target Vars: 51 and Alpha: 0.20

Base model: Orphan with Target Vars: 101 and Alpha: 0.20

Table of genes in models

(not running at the moment)

5 5000 Runs

5.1 C-Index distribution

Test set

Summary of C-Index and Log-rank

metric model base.model target.vars alpha mean std median min
C-Index (Test set) Hub Elastic Net 175 0.10 0.830 0.040 0.833 0.646
C-Index (Test set) Hub Hub 51 0.20 0.815 0.048 0.819 0.629
C-Index (Test set) Hub Orphan 101 0.20 0.827 0.042 0.831 0.655
C-Index (Test set) Elastic Net Elastic Net 175 0.10 0.842 0.036 0.845 0.655
C-Index (Test set) Elastic Net Hub 51 0.20 0.832 0.039 0.836 0.631
C-Index (Test set) Elastic Net Orphan 101 0.20 0.842 0.036 0.844 0.652
C-Index (Test set) Orphan Elastic Net 175 0.10 0.831 0.040 0.836 0.628
C-Index (Test set) Orphan Hub 51 0.20 0.817 0.045 0.822 0.57
C-Index (Test set) Orphan Orphan 101 0.20 0.827 0.041 0.831 0.618
Log-rank (Test set) Hub Elastic Net 175 0.10 0.008 0.024 0.001 5.53e-09
Log-rank (Test set) Hub Hub 51 0.20 0.012 0.037 0.001 6.46e-09
Log-rank (Test set) Hub Orphan 101 0.20 0.008 0.027 0.001 5.05e-09
Log-rank (Test set) Elastic Net Elastic Net 175 0.10 0.003 0.015 0.000 5.79e-10
Log-rank (Test set) Elastic Net Hub 51 0.20 0.008 0.028 0.001 1.93e-09
Log-rank (Test set) Elastic Net Orphan 101 0.20 0.004 0.016 0.000 8.22e-10
Log-rank (Test set) Orphan Elastic Net 175 0.10 0.005 0.020 0.000 1.24e-09
Log-rank (Test set) Orphan Hub 51 0.20 0.014 0.045 0.001 2.6e-09
Log-rank (Test set) Orphan Orphan 101 0.20 0.006 0.024 0.000 2.01e-09

C-Index Distribution

Rank

Elastic Net vs Hub
base.model r.squared
Elastic Net with target nvars: 175 alpha: 0.10 0.7517431
Hub with target nvars: 51 alpha: 0.20 0.6661319
Orphan with target nvars: 101 alpha: 0.20 0.6994452

Elastic Net vs. Orphan
base.model r.squared
Elastic Net with target nvars: 175 alpha: 0.10 0.9307745
Hub with target nvars: 51 alpha: 0.20 0.8799281
Orphan with target nvars: 101 alpha: 0.20 0.9025653

Hub vs. Orphan
base.model r.squared
Elastic Net with target nvars: 175 alpha: 0.10 0.7117327
Hub with target nvars: 51 alpha: 0.20 0.6083642
Orphan with target nvars: 101 alpha: 0.20 0.6548598

Train set

Summary of C-Index and Log-rank

metric model base.model target.vars alpha mean std median min
C-Index (Train set) Hub Elastic Net 175 0.10 0.924 0.006 0.924 0.904
C-Index (Train set) Hub Hub 51 0.20 0.865 0.011 0.864 0.829
C-Index (Train set) Hub Orphan 101 0.20 0.913 0.007 0.913 0.889
C-Index (Train set) Elastic Net Elastic Net 175 0.10 0.907 0.007 0.907 0.881
C-Index (Train set) Elastic Net Hub 51 0.20 0.869 0.008 0.869 0.84
C-Index (Train set) Elastic Net Orphan 101 0.20 0.906 0.007 0.906 0.881
C-Index (Train set) Orphan Elastic Net 175 0.10 0.906 0.007 0.906 0.881
C-Index (Train set) Orphan Hub 51 0.20 0.859 0.009 0.859 0.825
C-Index (Train set) Orphan Orphan 101 0.20 0.901 0.008 0.901 0.875
Log-rank (Train set) Hub Elastic Net 175 0.10 0.000 0.000 0.000 0
Log-rank (Train set) Hub Hub 51 0.20 0.000 0.000 0.000 0
Log-rank (Train set) Hub Orphan 101 0.20 0.000 0.000 0.000 0
Log-rank (Train set) Elastic Net Elastic Net 175 0.10 0.000 0.000 0.000 0
Log-rank (Train set) Elastic Net Hub 51 0.20 0.000 0.000 0.000 0
Log-rank (Train set) Elastic Net Orphan 101 0.20 0.000 0.000 0.000 0
Log-rank (Train set) Orphan Elastic Net 175 0.10 0.000 0.000 0.000 0
Log-rank (Train set) Orphan Hub 51 0.20 0.000 0.000 0.000 0
Log-rank (Train set) Orphan Orphan 101 0.20 0.000 0.000 0.000 0

C-Index Distribution

C-Index Rank

5.2 Log-rank test on Kaplan-Meier models

5.2.1 Log-Rank distribution

Cumulative

Distribution of Log-rank test with groups separated by high and low risk groups

Distribution

Distribution of Log-rank test with groups separated by high and low risk groups

5.2.2 Log-Rank Rank

5.2.2.1 Elastic Net vs Hub

base.model r.squared
Elastic Net with target nvars: 175 alpha: 0.10 0.1498939
Hub with target nvars: 51 alpha: 0.20 0.1467879
Orphan with target nvars: 101 alpha: 0.20 0.1153249

5.2.2.2 Elastic Net vs. Orphan

base.model r.squared
Elastic Net with target nvars: 175 alpha: 0.10 0.3461255
Hub with target nvars: 51 alpha: 0.20 0.3172004
Orphan with target nvars: 101 alpha: 0.20 0.3083969

5.2.2.3 Hub vs. Orphan

base.model r.squared
Elastic Net with target nvars: 175 alpha: 0.10 0.1766513
Hub with target nvars: 51 alpha: 0.20 0.1409792
Orphan with target nvars: 101 alpha: 0.20 0.1150030

5.3 Consesus genes

5.3.1 Selected genes over all runs

Bar plots of frequencies

Overlap between variables selected

Base model: Elastic Net with Target Vars: 175 and Alpha: 0.10

Base model: Hub with Target Vars: 51 and Alpha: 0.20

Base model: Orphan with Target Vars: 101 and Alpha: 0.20

5.3.2 Selected genes in significant runs

i.e. with pvalue < 0.05 in Log-rank test using the test set.

Bar plots of frequencies

Overlap between variables selected

5.3.2.0.1 Base model Elastic Net with target nvars: 0.10 alpha: 175

5.3.2.0.2 Base model Hub with target nvars: 0.20 alpha: 51

5.3.2.0.3 Base model Orphan with target nvars: 0.20 alpha: 101

5.3.3 Genes in Significant runs

i.e. with pvalue < 0.05 in Log-rank test using the test set.

Top consensus 20 genes

Gene Overlap total
EMP3 2 28931
CRTAC1 2 28875
WEE1 2 28572
CD101 2 27717
PTGFRN 2 27453
ARL3 2 26755
ITPRID2 2 26649
RAB42 2 25521
SHISAL2A 2 25449
CMYA5 2 24990
CEP112 2 24452
MGME1 2 23966
MYBL1 2 23191
LRRK2 2 22927
SRY 2 22845
HSPB1 2 22667
SLITRK5 2 22574
PLEKHA4 2 22278
MAP3K1 2 22041
SLC25A45 2 21758

All Genes

EMP3(28931), CRTAC1(28875), WEE1(28572), CD101(27717), PTGFRN(27453), ARL3(26755), ITPRID2(26649), RAB42(25521), SHISAL2A(25449), CMYA5(24990), CEP112(24452), MGME1(23966), MYBL1(23191), LRRK2(22927), SRY(22845), HSPB1(22667), SLITRK5(22574), PLEKHA4(22278), MAP3K1(22041), SLC25A45(21758), TEX26(21004), GPR1(20924), CCDC152(20608), FRA10AC1(20416), ERBB2(19500), SEMA4G(19335), SLC25A43(19202), CENPVL1(19188), EMILIN3(17846), RYR3(17715), ARNTL(17527), LCE5A(17445), GPR15(17111), DENND10(17023), DOK5(17003), LYPD6(16637), OAS1(16524), METTL7B(16449), FBXO39(16193), GAS2L3(16053), RASL10A(16000), KRTAP5-6(15904), TTF2(15883), ANGPTL6(15755), ADAMTS3(15597), PADI1(15311), DZIP1L(15098), NUAK2(15015), GPR156(14951), TGM4(14949), ACTR1A(14943), H3C8(14783), DESI1(14742), KLHL9(14514), PRKG2(14510), IGF2BP2(14386), FNDC7(14348), CDK2(14342), APOBEC3C(14316), PRDM10(13979), TMEM61(13864), PLEKHA2(13789), CDK6(13765), UBC(13665), RAC3(13573), SHISA5(13571), C11orf21(13557), CCDC87(13458), TGIF1(13400), SWAP70(13003), ERBB3(12834), POMC(12424), CYTOR(12384), JUN(12365), GNAT1(12180), SKI(12065), SERTAD2(12027), CCN4(11712), ACTL7B(11685), CABP4(11672), EVX2(11664), WT1-AS(11663), CD8A(11652), FSBP(11615), ARL9(11539), CREB1(11330), TMEM220(11322), FAM133A(11302), GRPR(11250), RPS6KA3(11110), CDK17(10997), IL17RC(10963), VSTM1(10951), MAGEA3(10767), CLIC1(10750), GSAP(10703), H2BC5(10508), BMP5(10477), FANCB(10430), MET(10420), HSPA5(10307), DIRAS3(10294), ABCC3(10178), HDDC2(9922), ZNF679(9873), MAP2K5(9849), DRAXIN(9773), GAS1(9769), TNFRSF12A(9708), SMC4(9670), TNF(9654), MAPK4(9638), TFRC(9554), GAS2L2(9500), CDK1(9496), ALB(9473), PIM1(9447), UBB(9445), IGFBP2(9444), UBL4A(9398), ARL14EPL(9396), IQGAP2(9392), GPR156(9352), FNDC7(9342), RGR(9333), OTOS(9268), RPP30(9255), CIART(9234), LMO7DN(9163), CAT(9155), ACTL9(9098), TIE1(9038), FBXO4(8982), FLT1(8914), MAP3K20(8861), CCDC8(8802), ABLIM3(8782), ARHGAP12(8694), SFRP2(8675), PDLIM5(8620), ACTG1(8615), GPR139(8507), CIART(8494), DNAH8(8440), STAP1(8432), LEP(8421), FNDC3B(8403), GAPDH(8353), GPR139(8313), ZNF648(8279), MORN4(8267), MAPK3(8252), PLAT(8231), RHOB(8202), CCN4(8093), ZNF648(8089), SULF2(8003), TOP2A(7935), SH2D4A(7931), TYRO3(7915), RNASE12(7911), ZNF474(7904), ADGRE5(7867), WT1(7827), KLK15(7793), VN1R4(7791), RHOU(7758), PARPBP(7714), STEAP3(7710), VWC2(7674), H4C4(7640), GALNT18(7635), H2BC14(7602), SDHC(7599), PER3(7592), FAM204A(7529), RGPD8(7512), ESR2(7499), BMP4(7487), IGSF10(7477), RNASE12(7477), HOXC4(7456), CDK4(7440), RPS6KA2(7415), LPIN3(7396), PLAAT2(7372), INS(7362), WFIKKN2(7359), UBL4B(7287), MAGEA6(7272), PMFBP1(7175), AL355916.3(7171), PBX3(7148), VWC2(7133), TP53(7130), ARL4C(7122), LATS2(7069), ACSM4(7044), MLLT3(7039), SAMD9(7036), HDAC1(7027), PPP3R2(7004), KLF10(6993), TPGS2(6969), H2BC14(6967), MKX(6956), SULF2(6945), CUEDC2(6929), TBP(6924), CCDC182(6908), ITGA2(6906), ANKRD20A1(6899), RAC1(6864), POTEI(6834), GNG12(6825), EVC2(6812), H2BC21(6798), ADCY3(6783), C8orf88(6776), KIF4A(6772), FNDC10(6734), PITX2(6727), CALM2(6660), GJC1(6659), EPHA2(6591), PLAAT2(6566), ACE2(6553), H3C7(6545), CALN1(6526), DMRTA2(6474), UTY(6439), NEDD8(6436), CALB1(6432), CA2(6426), CDK18(6401), CLDN8(6397), CABP5(6376), WFIKKN2(6363), ARAP3(6329), PRXL2C(6318), PPARG(6299), JHY(6288), ZNF630(6237), PHETA2(6182), LRGUK(6178), RHOA(6087), FOXB2(6046), MAGEA6(6019), OR4S1(6001), AC010255.2(5983), GOLGA6D(5979), NOTCH1(5964), DCBLD2(5902), OCIAD2(5890), CALML3(5883), TXN2(5878), TAGLN2(5852), ADRA2B(5844), INSRR(5844), FGF7(5831), AL672142.1(5826), AKT1(5800), CDNF(5779), BCL6(5745), NTNG2(5740), RND1(5733), TMSB4XP8(5612), SMC4(5579), BASP1-AS1(5574), ADCY10(5550), ACTA2(5541), MRFAP1L1(5534), LCE1C(5514), ZNF716(5511), RHOC(5477), GALNT7(5467), MYOD1(5455), ENOX2(5437), CYB5A(5436), RHOBTB1(5422), MSN(5389), TMPRSS9(5366), GALNT14(5304), STIMATE(5284), MMP7(5271), YWHAZ(5264), KRTAP19-4(5259), PTEN(5253), TSPO(5241), FBXW4(5227), PDGFRB(5221), MBNL3(5217), MAP3K19(5191), CD58(5191), TRIM6(5183), ELAVL1(5170), CHI3L1(5163), TPGS2(5157), EHMT2(5134), COL8A1(5127), PRSS56(5117), UGT1A9(5104), OASL(5081), LAX1(5058), ALG6(4987), RHOQ(4978), TRIB1(4977), MPI(4956), IGFBP2(4916), SMS(4913), BMP2(4913), ACTR10(4910), ACTRT2(4900), CFAP157(4882), RIN1(4875), ACTBL2(4847), MKX(4842), ZNF311(4841), SMIM27(4826), CDK1(4819), ALB(4788), AC093423.3(4779), UBB(4774), CPA6(4759), MGAT4C(4749), DCLK1(4745), TMEM92(4738), AC068234.1(4706), UBL4A(4667), TMEM237(4662), NAB2(4659), ENSG00000241978(4659), MAPK4(4654), AQP7(4645), BCL2L1(4642), SUMO2(4639), PPP1R36(4630), NDE1(4621), PER3(4615), SRC(4605), MAPK15(4601), HDAC1(4596), C2orf91(4564), PRSS35(4561), POGLUT3(4560), RAB34(4508), POTEJ(4499), MYC(4498), OR4M2(4460), CENPN(4431), MUSK(4426), H2BC12(4421), IFNB1(4404), MATN4(4368), CDK16(4360), ISG15(4335), STAC(4315), DCBLD2(4283), MTMR11(4261), WT1(4243), AOX1(4240), CDK4(4221), TRIM56(4219), RAD18(4214), CAD(4213), SP7(4202), PCSK1(4160), RGS22(4122), GRB2(4102), TFPI(4098), VAV3(4097), CNRIP1(4090), HRAS(4070), PRKN(4061), IGF1R(4056), NEDD8(4012), MEOX2(4008), BRCA1(3982), KIF24(3982), H2AB2(3975), GGH(3951), AL672142.1(3948), SAR1A(3938), TMPRSS9(3898), SERPINE1(3883), GALNT4(3883), HAUS7(3840), FAM171A1(3826), GDF10(3826), OLAH(3825), POTEI(3825), ITPRIPL1(3812), RBM43(3787), BDKRB2(3779), SLC19A3(3764), SOX13(3760), NRG3(3742), TAGLN2(3739), SAR1A(3732), RND3(3717), LAX1(3654), TNFRSF11B(3638), ADCY2(3630), RAD54B(3629), ARAP3(3625), VSIG10L(3588), OAS3(3583), DNAH8(3577), LIMK1(3575), PRR11(3571), SLC5A5(3558), EEF1AKMT3(3536), EEPD1(3530), SPATS2L(3523), GAK(3523), RAB11A(3522), AC093423.3(3514), MCUB(3512), ABCA12(3511), LCK(3506), FGFR3(3505), CEP135(3498), IFITM10(3486), MSN(3476), FGFR2(3476), MYO5B(3466), SNAI2(3457), ACTL7A(3442), RHBDF1(3437), POTEE(3426), MOS(3400), MYO5B(3398), RASD1(3389), DUSP21(3351), SCYL2(3345), F11R(3333), MAP2K5(3333), MARCHF5(3331), LYZL6(3325), ZNF217(3325), RARRES1(3302), ELK1(3301), MYB(3291), CLDN23(3289), UBD(3288), CPA6(3275), RHOD(3274), FLT1(3270), C9orf135(3269), FBN3(3259), DCBLD1(3252), PARPBP(3215), CCDC189(3204), ADPRH(3181), TRMT2B(3175), ITGA2(3172), KAT2B(3153), CHST15(3113), MROH2B(3106), C21orf62(3104), HJURP(3089), PLAG1(3069), TTC24(3060), LUZP2(3040), SP100(3020), IQGAP2(3014), IFNG(3004), LTBP4(2998), SLC6A14(2992), ZNF217(2964), H1-6(2961), SEC14L2(2946), HOXD12(2941), TOP2A(2923), SEMA3A(2913), RHPN1-AS1(2911), PIM1(2862), FAU(2855), OR4M2(2845), FAM83D(2835), FTMT(2805), NPSR1(2803), PLAA(2802), ACACB(2788), ASPM(2784), ZIC2(2768), RALGAPA2(2763), CXCL12(2759), FUT11(2757), MDM2(2753), REL(2752), CD302(2746), DSN1(2745), PRSS33(2728), EPOP(2722), H2AC4(2720), IL22RA1(2719), FBXO17(2708), HSPA1L(2699), RAD18(2696), RYR3(2696), C22orf39(2694), SMR3A(2681), COL22A1(2678), IHH(2664), DDIAS(2659), TNFAIP6(2659), SND1-IT1(2651), IL1F10(2634), IKBIP(2633), TMEM71(2621), SRGAP2(2613), PKIB(2603), MOXD1(2595), DNAH11(2589), FREM2(2587), RIPOR3(2574), MYB(2569), PLK1(2564), VAV3(2563), STK26(2561), FHDC1(2557), ERN2(2535), RNASEL(2522), AC245748.1(2497), GPR27(2493), ADAMTS12(2490), ACTA1(2490), PCSK6(2488), DNAJB12(2488), MORC2-AS1(2475), ERBB3(2466), IFIT5(2448), ARHGAP11A(2437), CFB(2433), EFCAB10(2411), TECTB(2402), DNAH11(2392), MARCHF9(2391), SPANXN4(2378), PDE10A(2371), NAB2(2361), PIK3CG(2355), ZFAND4(2353), FAM83D(2352), EPM2A(2352), G6PD(2350), EGFR(2345), MAPK12(2334), KIT(2322), E2F7(2315), CSNK1E(2313), OASL(2310), IZUMO1R(2308), RDM1(2305), SEPTIN9(2297), SPN(2282), SLC17A5(2276), RIPK4(2264), DDIAS(2256), PTCRA(2251), EYA4(2246), NPR1(2241), RFX1(2240), SEL1L3(2239), APPL1(2239), AC011455.2(2227), BIN3(2214), ITGBL1(2214), COX15(2184), PPP5D1(2165), CHP1(2163), PIK3C2B(2159), BIRC8(2154), GEM(2150), CCDC15(2149), SLC18A1(2147), TMTC1(2137), CCDC85C(2136), TTYH3(2124), HORMAD2(2122), TIMP1(2113), NTN4(2103), AC025165.3(2102), TTLL1(2087), FAM111A(2079), SAMD9L(2075), TTC26(2074), CKAP2L(2074), CDK5(2046), TREML4(2022), POMC(2001), AL139300.1(1994), TP73(1993), ERI1(1989), MEIS1(1987), TIE1(1987), BANK1(1985), EFHB(1971), SLC36A4(1959), OR10T2(1954), PIMREG(1951), OLAH(1946), EPHB3(1930), MAPK1(1928), FLG(1927), TBX21(1919), H4C15(1913), ACTG2(1913), FYN(1912), DUSP29(1908), CENPVL3(1906), TNFRSF11B(1903), SCAND2P(1895), TMEM163(1883), CFAP45(1879), LGR6(1875), AC010531.1(1874), BBS4(1871), SNAPC2(1860), MNX1(1860), ZAP70(1845), ABITRAM(1845), SPHKAP(1838), HFE(1826), TTC6(1818), EFNB1(1816), C10orf105(1812), ABLIM1(1808), CDK3(1807), SEMA3A(1795), CUL7(1788), ANKDD1B(1776), NFE2L2(1771), GLMP(1759), MALRD1(1757), WDR25(1756), ANKRD53(1748), C1orf141(1747), GLA(1746), H2BC9(1737), HJV(1735), AC006486.1(1731), TNFAIP6(1724), ACTR10(1719), CFB(1718), RASL11B(1718), FEM1C(1717), MX1(1716), PLPPR3(1705), C6orf58(1705), RHBDF1(1697), CFAP251(1688), MYH14(1681), REM1(1669), ADAMTS3(1667), RGMB(1667), FOLR1(1665), PPP1R1C(1661), IGF2BP2(1655), MAGEB5(1654), ANGPTL2(1651), AKT2(1651), ACTC1(1648), AC005837.2(1646), EFCAB9(1637), ZBED6(1637), GDF15(1628), ERN2(1627), NME1-NME2(1616), NEXN(1594), HMGN5(1591), DDX41(1590), REL(1589), ENSG00000260869(1587), PRKAG3(1582), MAT1A(1561), OTULIN(1547), MAGEB17(1544), SDK1(1534), OAS3(1534), EN1(1531), EPHA2(1531), RAB27A(1520), ABCA6(1520), CACNA2D2(1512), CT62(1512), FEZF1(1499), DMD(1499), LAMA2(1497), LY75-CD302(1485), LTBP4(1484), CENPVL1(1484), USP17L4(1483), CHMP5(1475), YY2(1461), CHIC2(1459), OR6T1(1459), SCGB1C2(1458), TTC16(1456), OR51Q1(1449), MYL2(1448), HOXD12(1446), TREX2(1444), PDGFRL(1437), AXL(1427), H1-6(1416), FOXB1(1415), ERVK3-1(1402), CCSER2(1401), OXTR(1396), CHRND(1394), H3C13(1393), SFTA3(1390), POLR3H(1385), TSPAN3(1382), SEL1L3(1381), TCEAL2(1380), GPM6A(1377), MX1(1373), OTP(1371), IER5L(1357), C10orf55(1350), LINC00472(1349), TBPL1(1347), SPOCK2(1344), DES(1343), APOE(1341), FOS(1336), TTC7A(1330), COL19A1(1324), TMEM140(1316), FOXK1(1316), BST1(1315), FHDC1(1312), TADA2B(1311), CDH1(1306), PEX7(1304), APCDD1L(1291), TMEM87B(1290), CDCA2(1287), FAM111B(1286), GNL1(1279), SPN(1278), COX15(1276), RND1(1276), RAP2C(1275), CDKN2C(1272), ENSG00000278500(1269), SFRP2(1266), AADACL4(1260), KRTAP5-6(1257), DSG3(1255), OR2W1(1254), DBP(1250), BCAT1(1249), FBXW4(1248), CLEC19A(1247), AL354761.1(1246), KLLN(1246), CWF19L1(1245), ASB13(1245), ENSG00000278272(1237), H3C4(1235), SHOX2(1232), CNMD(1231), CBFB(1229), SFMBT1(1228), PCDHB16(1227), TSSK1B(1224), SLC16A1(1223), FGFR1(1217), EN1(1211), FAM110C(1208), RAB27A(1208), PCSK5(1208), NELFCD(1206), BCAT1(1206), H2AX(1198), ZNF592(1196), VRTN(1195), BEND2(1193), TMEM179(1193), BVES(1187), PRKAR1A(1185), FLT3(1181), TMEM212(1179), MAPK14(1179), EFCAB3(1175), ANGPT1(1174), EYA4(1172), SCNN1B(1164), EFNB1(1157), PRSS33(1149), TROAP(1143), WNT10A(1142), EMP1(1141), CA2(1141), IRX5(1138), LOXL4(1133), SOGA3(1129), AC005702.1(1128), HERC6(1127), PRICKLE3(1124), SGCA(1123), LINC02872(1122), IFITM3(1121), ECHDC2(1121), BIRC8(1113), HSPD1(1112), HELZ2(1099), ARHGEF19(1099), UNG(1096), GATA6(1094), SGCG(1092), ZSCAN2(1088), APOBR(1087), KLF17(1083), PGM1(1080), TRIO(1074), GAGE12H(1074), ARSL(1073), SPATA3(1073), KHNYN(1067), GAS8(1067), CCL19(1066), TP63(1060), AGMO(1058), UBALD2(1048), TOM1L1(1045), FAM126A(1043), KIF13A(1040), HACE1(1040), KLHL33(1039), ADCY3(1036), NR2F2(1035), TREML4(1031), OR4C13(1029), HOXA1(1022), PPP2CA(1020), KLHL25(1016), TRIM49D2(1016), CDC20(1015), EPM2A(1010), HSPA1B(1010), AOX1(1009), TRPC5OS(999), RNF212(996), GGT2(993), RHOQ(991), ACTR8(989), TSPAN31(985), C17orf77(985), ASPN(984), TBC1D10A(982), EFHC2(982), C5orf66(981), GATA4(980), ARMCX2(979), OR5W2(973), SGCD(973), MRPS16(969), TUBB1(968), PLA2G2A(968), FAM86C1P(966), TM2D3(965), TOMM34(965), ESR1(963), C1orf105(960), HSPA9(957), TIMP1(954), ANGPT4(952), PRKX(950), IGFBP5(949), PRDX3(940), FAM166C(939), CENPF(936), CDY2B(934), ARHGAP23(931), CYP3A5(921), H1-2(920), SYT14(919), SERPING1(918), BEAN1(917), PTK6(916), RASSF10(915), CEACAM1(913), ARHGAP11A(908), NSUN7(907), WDFY2(903), AC005020.2(900), TICAM2(896), IGF2BP3(893), GALNT5(891), GALNT3(887), ECT2(887), MTAP(884), DES(883), SMR3A(881), CRACR2A(880), PRKACB(880), LOXL3(877), SEPTIN9(877), SUMF2(874), BDNF(873), DUSP10(872), TMPRSS11D(871), LAMA2(871), TAC4(868), SRPX2(866), IL6(859), TRAM1L1(858), CNTRL(856), GLI2(853), MAGEB5(846), CCNY(845), PNPLA6(840), RIPK2(840), HOPX(839), PPARG(839), RNF187(836), RANBP2(836), RERG(830), BMPR1A(829), ABO(826), LYZL6(826), SDHC(823), PBK(821), TCP11X2(819), PPM1L(818), MGAT4C(818), TSTD1(817), PCDHA2(810), MRPL43(803), SULT1E1(802), CAPN1(798), LRRC27(798), BORCS7(798), FEM1C(798), TRIM61(793), H2BC17(793), CARHSP1(792), GTF2H5(789), AL355916.3(787), STPG4(786), PCDHGA9(786), CDCA8(782), ANXA5(779), CUBN(777), PRAMEF4(777), REXO2(776), ARHGEF10(774), IZUMO1R(773), CIP2A(769), CPS1(768), ENO1(767), PROC(763), PTPDC1(758), ENSG00000278500(749), KLRF1(747), METTL27(747), SAA1(746), TUBB3(746), ACSS2(745), STUM(743), ACTL10(742), PAX5(737), ZFPM2(735), PADI1(734), SSTR2(731), MICU1(727), SUFU(726), TPRG1(720), KRAS(720), NREP(717), KCTD14(717), GUCY2D(716), MIS18BP1(715), HPS6(715), SSUH2(712), SBNO2(709), TCF7L2(709), CXorf49(708), SIGLEC5(707), GCAT(705), WASF4P(702), PINLYP(701), KIF18A(699), SEMA3B(697), EFHB(695), COLGALT1(693), BCR(692), ZNF404(691), ZYG11A(690), CABP7(690), EPHA3(689), PRAM1(687), BCL2(686), PLSCR1(686), MNS1(684), C1GALT1C1L(680), SAMD5(677), ITGB3(677), FOSL1(675), OAS2(674), KRT15(673), CUL7(673), HSP90AA1(673), PPM1L(669), FGFRL1(667), TRIM14(666), MTMR3(660), GRIK4(660), TMPRSS3(660), AGTR1(660), BCORL1(659), AC099811.2(658), MRPL1(655), BEX3(652), ARMC9(651), DNAH9(651), PNMA1(650), SCN10A(650), BUB1(649), DMD(648), TNK2(645), PXDNL(645), EPRS1(645), RAD51D(641), LIMCH1(640), AC093155.3(638), APOBEC3F(637), SPAG1(637), TCTEX1D4(635), DEFB110(631), MN1(630), AFAP1L2(626), RABL2B(626), FKBP1A(622), CRY2(619), MT3(616), ADCY8(616), SLC7A13(614), CDK15(613), DPY19L1(612), INO80B-WBP1(605), TUBB2A(605), CAMSAP3(604), CDC25A(603), FTH1(603), SLC2A9(599), KLHL4(598), MFNG(597), TENT5A(585), FAM229B(585), GLUD1(584), H4C8(583), POLR3H(583), GSX2(580), GNAT3(578), IRAK2(576), PLP2(572), NOL4L(566), LINC01565(563), FRMD8(562), HDAC9(562), EEF1A2(561), AC092143.1(561), CLEC18C(560), LMNA(560), ACTL10(560), AC117457.1(560), ZSCAN20(557), AQP11(557), LY75-CD302(557), UMPS(557), AC110275.1(556), NEIL3(553), RADIL(553), PRKAR2A(551), ACSM3(547), ERGIC1(546), RERGL(542), AL354761.1(540), BTK(539), RPS6KA1(538), CYP27B1(535), IER5(534), FURIN(534), CCNJL(533), AQP1(533), SGCA(532), CTNNB1(532), GALNS(531), WDR41(530), MYO3B(528), SLC35D1(527), TEX9(526), SLC4A7(525), FGF21(524), CDH1(522), TEF(517), ZNF516(515), SLC22A2(515), AQP12B(514), FOXK1(512), TSPAN19(510), DGCR2(509), ATP2A3(508), ZMYND8(508), ACRV1(507), MORC4(506), ZNF705B(506), ALDH9A1(503), MED14(503), ACCSL(502), PTAR1(500), FDPS(499), RPS6KA4(497), CCDC89(494), CRYL1(493), AP001458.2(493), C1orf112(489), CCZ1B(489), RHOJ(488), ZNF516-DT(486), CENPO(485), FOXM1(482), FOXN1(474), CD24(473), FLII(472), IL23R(469), ANKRD16(469), LIPC(468), TPX2(468), RTTN(466), THBS4(463), PRKG1(459), RALA(457), DMC1(455), KRTAP22-1(453), BRCA2(453), PCCA(453), NDN(453), FLG(450), OR6P1(447), IRX5(447), GRIN3A(446), CAPN8(446), UPK2(445), PCSK2(444), GLUD1(443), GDPGP1(442), ATP2C2(441), RAB34(440), PRSS37(439), FANCD2OS(438), PGM1(438), RIF1(435), ANKEF1(434), FGFR4(432), CCT6A(431), MYOZ2(431), HERC6(431), DIRC1(429), SP6(428), B3GAT2(427), COL28A1(427), RASGEF1C(426), WDR88(426), UMAD1(425), CCND1(424), UNG(423), GSG1L(421), TXLNB(420), NPAS2(418), KRT15(417), MAPK8(417), RET(417), SPRY2(416), LCTL(415), UGCG(415), VRTN(414), HDAC7(414), TBC1D1(414), EPOP(411), MAS1L(408), FABP6(406), CYP3A5(404), SUMO4(403), PNPLA7(402), SHANK2(401), KRT80(401), CAPG(400), ADAMTSL2(399), EFCAB13(399), CMTM1(398), TRAM2(397), GPR15(397), PDE7B(396), TUBB1(395), XAF1(394), FXYD6(393), PITX2(391), SLC25A28(390), NUDCD1(388), SGCE(387), TMEM184A(387), VHLL(387), SDK2(386), IFNE(386), PLCG1(385), PTPN22(385), RGPD4(385), HOXD4(384), ARSL(382), H3Y2(381), NEK2(381), ZNF888(380), ATP1B4(378), H1-2(378), TNFSF11(378), CHAD(377), MACC1(376), IGFBP5(376), SGK1(376), DUSP10(376), MRPS16(376), CR1(375), NFE2L3(374), FAM181A(374), MARCHF10(371), SGO2(370), RNF185(368), GNA12(368), C14orf132(368), FMO5(366), HSPA1A(366), DCLK2(364), AC013470.2(363), EPHA3(363), NUTM2A(362), CIRBP(360), COLEC11(356), OVOL3(356), ADH1B(355), CSNK1E(355), ATR(354), BASP1-AS1(354), HS6ST1(353), IQCB1(353), GIPC3(353), LINC00671(349), USP28(348), ACSS3(348), AADACL4(346), MYD88(345), GSTA1(345), CTAG2(343), TERT(343), DYNAP(340), TRIM8(339), ACTL8(337), INSR(336), TP63(334), IGF2BP3(334), MAP3K5(329), DACT2(328), PIK3IP1(328), HAO1(328), ARHGAP18(327), ADAMTSL4(324), EPB42(324), IMP3(324), AKAP14(324), CCDC153(323), PSRC1(322), LRRC20(322), SCGN(322), H2BC17(322), YES1(320), AL136295.3(320), SMARCB1(319), HOXD3(319), ENSG00000241978(319), KERA(319), C6orf99(318), H2BC18(318), SCP2D1-AS1(317), PBX3(316), RAB11B(316), OTX1(314), ZNF468(313), CHRNB4(311), LINC02817(311), ADAMTSL1(310), YWHAE(309), PWP2(308), SOX5(307), CDH2(307), LDLRAD2(306), AC034102.2(305), TRIM16L(304), RASL11A(303), ZDHHC22(303), ADAMTS20(302), NNMT(301), H2BC11(300), TRIB1(299), GTF2H5(299), TUBB4B(298), MAP1LC3C(295), MAGEA2B(294), BEND2(293), JAK2(293), CHAT(291), CHMP5(291), TRMT2B(291), PLPP6(290), MYEOV(290), MTAP(290), YY2(290), PPP1CB(289), DTX3L(288), H2BC4(288), AC002310.4(287), H2AC1(286), MT1A(286), RASL12(286), ZNF816(286), SIRPB1(285), CD274(281), HOXD13(280), S100A16(279), ALDH1A3(278), MAP3K19(278), PALM3(276), C1orf105(275), PRR20A(274), OR6N2(273), THADA(273), PRKACG(271), CASP9(270), EPHB2(270), CDC5L(270), JAK1(269), IL13RA2(268), OR14A16(267), GSTA4(266), DCDC2(266), NADK(265), H4C9(265), ITGA3(264), ZBP1(264), FRMPD1(262), ART4(262), TMEM154(262), ZDHHC13(262), BTN2A3P(261), RAP2A(260), ATP6V0E2(259), ZNF843(259), IQGAP3(258), SHOX(256), TMCO2(256), TMEM254(255), NFIB(255), PIP4P1(255), SAP18(255), AL355315.1(255), PLA2G5(254), BEAN1(254), TMEM26(253), GOLGA2P7(253), MEIS1(253), CCT3(253), SLC35G1(252), LGR5(252), METTL11B(251), WDFY3-AS2(250), PSPC1(249), RGPD6(249), NRAS(249), KIAA0040(249), ZNF32(248), CCNB1(245), GDF3(245), ARHGAP18(243), PTPN23(242), GSR(242), RGPD2(241), USP29(240), OR5AP2(240), H4C8(239), ANGPT4(238), SYNE3(238), PPP2CB(238), HSPA4(238), CXCL12(237), OPLAH(236), C13orf42(236), DDIT4L(234), H3C12(233), FOXD1(233), OR2W1(232), PSMD5(231), GALNT16(231), CUTC(231), IFI6(231), CAPN5(230), VWA3B(230), MBOAT1(230), COL6A1(229), CDC14A(229), FBP2(229), PRAMEF5(228), RAP2B(227), MAPK11(227), RAI2(226), RHOBTB3(226), P3H4(225), LPP(224), CPA4(223), ULBP3(223), GAREM2(223), PPEF1(222), APP(220), VGF(219), PARP10(218), AQP1(218), LY6G6F-LY6G6D(217), ATP2A3(217), CASP8(216), CARHSP1(216), PADI3(215), CTDSP2(215), C7orf69(214), DPP4(214), TCP1(214), TK2(214), EPHB2(213), WDR31(213), ADAMTS5(212), XKRX(212), STK40(212), ACTB(212), DEPDC1(211), GSX2(211), FOXA3(210), PCDHB1(208), MFNG(208), OTX1(208), FOXI2(208), ZNF177(208), SNCAIP(207), MFSD13A(206), KIF19(206), MRPS10(206), HMGB1(206), C9orf40(205), RFT1(205), TEKT4P2(205), STK38L(205), OR4M1(204), C2orf91(204), XKR3(203), FOLR2(202), KIF2C(202), FAM111B(202), RPTOR(201), CCDC81(201), FAM161A(201), FPGT(201), ARNTL2(200), STBD1(200), IFT80(200), FKBP10(199), ARSJ(199), AQP3(199), PCCA(199), OPN1LW(198), OR5W2(198), DECR1(198), FOXA1(198), H3-4(198), PHLPP1(197), LUM(197), FSTL5(197), AL136295.1(197), SHH(196), URAD(195), ATP6V1G2(195), UGT1A7(195), FAM156A(195), ABI1(195), RRAGA(194), KLHL9(194), SUFU(194), NEMP1(193), DTHD1(193), GATA3(193), RWDD2A(192), AC105052.1(192), MRPS27(191), NOS2(191), NEIL3(191), HORMAD2(191), NPL(190), AL033529.1(189), TRIM34(189), C5orf34(189), SCML4(188), VGLL2(188), FAM122B(187), PDCD1LG2(187), OGN(187), ST7L(186), OSR2(186), FAM170B(186), MUCL1(183), VPS26A(183), RBP1(182), EPB41L4A(182), H1-8(182), ATP7B(181), HSP90AB1(181), KAT5(181), ARC(180), EED(180), CLDN18(178), NCAPD2(178), FAM182A(177), ZBTB18(177), C1orf112(177), MDM2(177), EPHA1(177), RRAGB(175), SMIM10(175), SLC25A24(175), ZNF888(175), CCDC87(174), AMTN(174), RHPN1-AS1(174), MARCKS(174), FKBP5(173), HDGFL1(173), NCBP2L(173), ANKRD60(173), GFI1B(172), PTAR1(172), ASB5(171), MAP3K15(171), NBPF26(171), CSNK2A2(171), LIPC(170), TTC39C(170), PGAM1(170), PLEKHO1(169), AVIL(168), EGR1(167), PHYHIPL(166), MT1B(166), OLIG3(166), ZAP70(166), FANCD2OS(166), ZAR1(165), MT1M(165), CREM(163), NR1D2(163), FOXG1(163), USP4(162), WDR72(162), JUND(162), TNS3(162), CYB5D1(160), FZD2(160), GPC1(159), IGFL3(159), KIF14(159), EEF2(159), SHC4(157), CASQ1(157), GIPC2(156), CTSG(154), PLAGL2(154), SNX18(154), NSUN7(154), CCDC138(154), ASPG(154), AC120057.2(154), RAB18(152), ZMAT2(152), GRID1(152), ERAS(152), SLC22A12(151), SCD5(150), KIAA2012(150), GH1(150), H2AC6(148), TMEM211(148), DIRAS1(148), TRAF5(147), ASCC1(147), GNA11(147), SMS(147), HIPK1(147), ERG28(146), AP1S3(146), IL23R(146), STK38(145), ANKRD16(145), PDLIM5(145), HINT3(144), NADK(144), FLOT2(143), ADAMTS14(143), NOS3(143), MOB3B(142), DOCK11(142), SPRY4(142), HOATZ(140), ASPM(140), SERF1A(139), NUDT2(139), PRKACA(137), DLK1(137), BID(136), ITGB8(136), IFI44(136), CGREF1(136), LILRA4(136), KIAA0753(136), HPSE2(135), LOXL1(135), SLC8A3(134), SGCE(134), RRAD(134), SCMH1(133), TRAF3(133), EPHA4(133), MCM8(132), SIK1(132), CDKN3(130), NUGGC(130), TG(129), ACTRT1(129), KLF16(129), FGF2(129), PRSS58(128), STIL(128), DYRK3(128), RAG1(128), MAB21L1(128), METTL1(128), RBP1(128), SHD(127), COL26A1(127), ACTRT3(127), RAB38(126), ATM(126), UBAP1(126), MAOB(125), CFAP65(125), CHEK2(125), PDGFA(125), MEN1(125), ADGRA3(125), CRYL1(125), DEFB125(125), UGT2B17(124), BAG1(124), C6(123), PDLIM4(123), CLEC18B(123), KIAA1671(123), MUC12(123), SKP1(123), GCNT3(122), SLC11A1(122), MMP9(122), CASK(122), PRKCA(122), TP53I13(122), AR(122), AL591806.2(122), NANOS1(121), MCAM(121), SIN3B(121), C14orf132(120), GOLGA6L2(119), DEFB110(119), CKLF-CMTM1(119), EYA4(119), H2BC11(119), ZNF597(119), TMEM200C(118), NME3(118), RABL2A(118), OPLAH(118), CTAG2(117), LSP1(117), PLEKHG4B(117), ABL1(117), THBS4(117), HSPH1(117), CIP2A(117), APOC2(116), HOXA5(116), HSPA8(116), CCKAR(116), SLC22A4(115), KDR(115), FKBP9P1(115), PCDH15(114), KLF5(114), BANF2(113), DNAJA1(113), PPP3CC(113), ZSCAN20(113), IRAK2(113), RPS6(112), GALNT3(112), FZD6(112), CDKN1B(111), CCL19(111), IDH2(111), ATP10B(110), VASN(110), P2RY6(110), OR6N2(110), KRT80(110), RAD51B(110), SAYSD1(109), PHTF1(109), FLACC1(109), ZNF525(109), RAD51(109), YWHAG(109), TOX(109), OR4C13(109), DMAC2L(108), ZCCHC4(108), PDLIM4(108), LRRC52(108), BEX3(108), TUBB8B(108), FAM167A(107), GDPD2(107), REN(107), OR14A16(107), SLC22A17(106), TAB1(106), BRS3(106), GGACT(106), RAB7B(106), BRCA2(106), GCK(104), PLCG1(104), MFAP4(104), VASN(104), NPAS2(104), HDAC3(104), GSTA1(104), HIF1A(103), CNBD2(103), KIF27(102), DMRT2(102), AL049839.2(102), STK32B(102), MPZ(101), PEA15(101), WNT10A(101), PHYHIPL(101), EFCAB9(101), SLC4A7(100), OVOL3(100), CAAP1(99), FAM86B1(99), CACNA2D2(99), RAB18(99), SLC25A48(99), SLX4IP(99), GP1BA(99), GRIN3A(99), PSIP1(98), ATG10(98), OR51T1(98), TRIB2(98), SNAI1(98), ISL2(98), KDM2A(98), IDI1(97), ODAM(97), PPP1R15B(97), SETD2(97), CCDC160(97), BIRC5(96), MSRB2(96), KIF20A(96), MTOR(96), HSPA1L(96), C6orf62(95), COLEC11(95), EIF2AK4(95), LRRC4(95), CHP2(95), TRIO(94), MAPK6(94), ABL2(94), TBC1D3K(94), CRLF1(93), CDC25B(93), TCF21(93), RCL1(93), CLDN12(93), FGF10(93), RAP1A(93), UTP20(92), CCDC70(92), SCP2D1-AS1(92), HKDC1(92), LEF1(92), H4C9(92), CCDC115(91), FSTL1(90), DACT2(90), FAM72B(90), IL10(90), ADRA2A(90), WASHC2A(89), E2F8(89), SEMA3A(89), STK32C(89), TMEM159(88), SOX9(88), LINC02870(88), AKAP1(88), PRDX2(88), MID1(87), DLC1(87), FAM120AOS(87), RAD18(87), SLC22A17(87), NPR3(87), MS4A13(87), SLC38A4(86), TMED5(86), HP(86), CCDC194(86), NFKB1(86), SIRPB2(85), AKNAD1(85), KCNK17(84), PRSS41(84), YY1(84), CDCA8(84), MID2(83), CELA1(83), PSG9(83), PLEKHN1(83), GLI1(83), ENO4(83), SLC2A10(83), CAPN8(83), MGAM(83), PACSIN2(82), PHEX(82), RGS9(82), TGM4(82), SHPK(82), MYO5C(82), TKT(82), SAMD8(81), ADAMTSL1(81), MIR1915HG(81), PCDHA13(81), TYR(81), FAM71D(80), HTR1D(80), FAM83G(80), OR11A1(80), AC005832.4(80), ALDOC(80), HOXD13(80), ZFYVE27(80), KATNIP(79), PSMD5(79), CDH26(79), CCT6B(79), PADI3(79), XKR8(79), RRAGB(79), PTTG1(79), SP5(79), LPP(78), ASB5(78), MIR1-1HG-AS1(78), LPIN2(77), PSPC1(77), HSD17B6(77), EPHA7(77), OTULIN(77), CFB(77), RNASE12(77), DUSP4(76), WNT2B(76), SLC26A2(76), NAXD(76), ERICH1(76), GPX7(76), PATE3(76), CCND2(75), REPS1(75), TASOR(75), HEXB(75), SAA2-SAA4(75), IL27RA(74), TMEM100(74), FSBP(74), PLOD3(73), SEMA5A(73), CRIPT(73), OR4A47(73), ITGAV(73), CNTNAP3B(73), CDC25A(73), DMRT1(72), TM9SF3(72), IFT74(72), WBP2(72), MMP7(72), TDRD12(72), EHD2(71), UST(71), DIAPH1(71), PLA2G6(71), PLOD1(71), CYP2S1(71), ZBTB14(71), SERPINA5(70), PLPP6(70), AC092587.1(70), ACLY(70), MXI1(69), FABP6(69), MUC6(69), ZNF808(69), UBQLN4(69), H3Y2(69), MYOM3(68), SIGLEC1(68), RPL3(68), ACADL(68), IGFBP3(68), KRT13(68), SPANXD(68), GJE1(68), AC026464.1(68), TMEM159(68), HSPA12B(68), RCC1L(68), BEST4(67), OR7A5(67), AVIL(67), GPX8(67), TSPYL6(67), SRGAP2(67), EYA3(66), SCGB1D4(66), UBE2Q2L(66), CMTM1(66), MYO9B(66), DHX58(66), TEK(66), UBXN10(66), OR5BS1P(66), TENT5B(65), CFAP20DC(65), ACER1(65), VSTM2A(65), BCCIP(65), SERPINF1(65), OS9(65), CENPE(65), SLC35E3(64), FAM9B(64), PDX1(64), CDHR1(64), RSPH10B2(64), DGCR6(64), THADA(64), EPHB1(64), SLC16A9(64), RNF215(63), IFI27L2(63), NR3C2(63), MAML3(63), H2AC7(63), CRLF2(63), TMEM140(63), NFIB(63), MAPK7(63), POSTN(62), NDUFS4(62), C1orf185(62), GOLGA8O(62), ARL14EPL(62), RNF170(62), SLC13A3(62), HIF1AN(62), DCLK2(62), ADD3(61), PTX3(61), C15orf54(61), CCER2(61), CFLAR(61), TGFB1(61), GLI3(61), DNAJC12(61), ALDH5A1(61), FTH1(61), LRIT2(61), BMPER(60), P2RX1(60), TRPM8(60), MC2R(60), RTL9(60), CSAG2(60), TIGAR(59), GRAMD1C(59), MAFB(59), ANKRD42(59), COL6A1(59), PDCD4(59), POLR1C(59), H2BC12(59), PRDM16(58), AKAP4(58), JUP(58), FER1L6(58), HNRNPCL2(58), KCNIP3(58), SUMO1(58), EMILIN1(58), CEP85(57), SLC52A1(57), SELENON(57), KLHDC8A(57), OR10G2(57), NET1(57), HSD3B1(57), ZNF723(57), TBX15(56), SIRPD(56), C7orf69(56), PCNA(56), MYH11(56), TIAL1(56), TAFA3(56), APOBEC1(55), MORC1(55), ADAM33(55), KLRC2(55), AC140504.1(55), AURKA(55), ENO3(55), SOD2(55), CCDC194(55), TNKS1BP1(54), B3GNT7(54), GLDN(54), ITGA3(54), TRAF5(54), SOX5(54), BORCS7(54), MARS1(54), CAPS2(54), APOBEC3G(54), H4C14(54), PAMR1(53), F2RL2(53), SFT2D2(53), DCDC2C(53), CNNM2(53), ORAI1(53), OAZ2(52), SACM1L(52), CDK14(52), RASD2(52), HOXD3(52), SUN1(51), FCRL6(51), APOBEC3D(51), PPP5C(51), ALG1(51), TMEM255A(51), DAB2IP(51), TM7SF2(51), MR1(51), RRAGA(51), PRKAG1(51), TMEM244(51), PABPC3(50), GOLGA8J(50), COL18A1-AS1(50), MTRNR2L1(50), PRR11(50), SPP1(50), RRAS2(50), PCSK6(50), OR9G4(50), NIM1K(50), SEPTIN9(50), IFT27(49), KRT5(49), MSR1(49), GNA12(49), ENOX2(49), UBE2C(49), UGT1A7(49), ABCB4(48), SLC27A3(48), ICOS(48), SLC7A13(48), XPO1(48), TAF1L(48), OSR1(48), ZNF80(48), EPHB4(48), DNAAF4(48), BRINP1(47), TNFSF14(47), FRAT1(47), PCDH7(47), PLK3(47), MYO3B(47), PDGFRA(47), KLF4(47), SPIN4(47), AC026786.1(47), AC020922.1(47), POLD3(46), VNN2(46), FAM182A(46), NHP2(46), HSFX1(46), CHST4(45), CFHR3(45), ARG1(45), TAPT1(45), PAWR(45), ZNF443(45), DNAH2(45), KANK2(45), MDM4(45), ENSG00000274267(45), UBE2I(45), SDC1(45), IL13RA2(45), ATP1A4(45), ASB17(45), CFAP157(45), TSSK3(45), ZNF816-ZNF321P(45), TICAM2(45), ABRACL(44), PLA2R1(44), FRMD7(44), RFWD3(44), CLDN20(44), MOB1B(44), CYS1(44), FGR(44), PDGFRL(44), HOXA7(44), PRPS1(44), TRAT1(44), TERT(44), NBPF26(44), XPNPEP1(43), BCL2L11(43), UBASH3B(43), FAM91A1(43), KRTAP22-1(43), FAM221A(43), RAB38(43), ODF2(43), DRD2(43), RIT2(43), ADAMTS5(43), ZNF438(43), LINC00672(43), PMS2P5(42), SERP2(42), SUGT1(42), MBL2(42), THBS3(42), KCNE5(42), KRTAP10-9(42), PRECSIT(42), H3C6(42), AQP8(42), CCDC18(42), ATP7B(42), WDR41(42), DIRAS2(42), C1orf87(41), CST9(41), TEAD2(41), MEST(41), TRAF3(41), TRIM34(41), BOLA2-SMG1P6(41), CMTM6(40), TULP2(40), ALDOB(40), CCDC175(40), SLC6A20(40), OR10H1(40), KRTAP10-6(40), FAM114A1(40), CDRT1(40), ELN(40), GRK3(40), FOXO1(40), PTX3(40), IL3(40), ZNF32(40), PNMA1(40), OR4C6(40), DEFB116(40), SMIM27(40), CYP24A1(39), ACSM2B(39), SEMA3E(39), NKX2-5(39), NCMAP(39), CFTR(39), TPX2(39), SMAP1(39), IFIH1(39), UBE2D2(39), SLF1(39), ANGPT1(39), IFT122(39), BUB1(39), IGIP(39), ATP6AP1L(39), CYB5RL(39), AC010542.3(39), AC011455.2(39), XRN2(38), FBXO6(38), CRYGD(38), ARL5C(38), RMI2(38), LRRC75B(38), S100A5(38), FKBP1A(38), LSP1(38), FAM91A1(38), MPHOSPH8(38), PRAMEF5(38), SLC35A3(37), POLR3GL(37), ACOT9(37), SCML4(37), VANGL1(37), ZNF860(37), AC137834.1(37), TMEM230(37), CSK(37), HOXA2(37), DNM1(37), HSPA2(37), CNPY4(37), TMEM211(37), AC010255.2(37), AC010422.6(37), ATP13A3(36), CTTNBP2NL(36), CCDC103(36), PSORS1C2(36), BTBD19(36), TMED7-TICAM2(36), H2AC8(36), FREM2(36), CDK19(36), FAM120AOS(36), CCDC85C(36), GDF10(36), LDHB(35), MTIF3(35), WNK4(35), CRYGA(35), TACSTD2(35), AL365232.1(35), ISY1-RAB43(35), MAP2K3(35), RHEB(35), GRPR(35), SEMA6B(35), RGPD8(35), TMPRSS9(35), MAP3K5(35), NUP62CL(35), PRKDC(35), AC073612.1(35), SATB2(34), CMTM3(34), SLC16A12(34), MAGED4(34), RBPMS(34), CATSPER2(34), RPRM(34), SHC4(34), TTC25(34), CDC42(34), ABLIM1(34), SFMBT1(34), RHOH(34), TEAD3(33), BEX4(33), TMEM123(33), SIM2(33), GPR85(33), OR12D2(33), TTK(33), USP4(33), FRMD8(33), ERG28(33), EDNRB(33), ZMAT2(33), PPEF2(33), SPNS1(33), ARAP1(33), CHCHD2P9(33), FAM72B(33), CPM(32), ZNF618(32), PSIP1(32), SIMC1(32), GPR141(32), INSYN1(32), LILRA6(32), SLC8A3(32), BMX(32), TNNT1(32), CD79A(32), MATN4(32), FKBP10(32), CLPB(32), ARL14(32), AC004691.2(32), CBFA2T2(31), RNASE8(31), OR4M1(31), B3GNT5(31), NMB(31), AL669918.1(31), GPC1(31), IDI1(31), SRF(31), IL22(31), CHRNA1(31), CCDC15(31), RAG1(31), TMEM92(31), SLFNL1(31), SERPINA5(31), NANOS1(31), GNL1(31), CLEC12A-AS1(31), TBX5(30), CHCHD2(30), TFCP2L1(30), PTPRQ(30), HGSNAT(30), CTBP1-DT(30), PITX1(30), ZNF516(30), E2F8(30), YWHAQ(30), EPS8(30), AP1S3(30), ATAD2(30), PDPN(30), ENPP6(30), NLRP11(30), IRAK1(30), FOXD4L3(30), SP6(30), CCER2(30), LRRC42(29), RBM38(29), IFNA5(29), GHITM(29), GPR19(29), CCNE1(29), ITGB8(29), PRDM13(29), TMBIM1(29), EFCAB11(29), CDHR1(29), ATP5F1A(29), FOLR2(29), WDR72(29), ARSJ(29), CYB5D1(29), LRRTM3(29), FAM24A(29), LINC02872(29), C4B(29), STIMATE-MUSTN1(29), SRRD(28), PI15(28), SLC25A37(28), TFDP1(28), AL049634.2(28), PLAUR(28), FOXP3(28), TNK2(28), OAT(28), WASHC2A(28), CDC25B(28), RND2(28), MKKS(28), PLAGL2(28), PLA2G5(28), PLCE1(28), ARHGEF19(28), NEMP1(28), MAP3K11(28), NOG(28), CIB1(28), RASSF10(28), MMP1(28), FLNA(28), PPP1R11(28), PROM1(27), SCGB1D2(27), LRRC9(27), PTGR2(27), LINC00301(27), C12orf60(27), PRSS58(27), ARHGAP19-SLIT1(27), NEK6(27), HELZ2(27), ALLC(27), CETN3(27), KIF15(27), OR5A2(27), ABRA(27), H1-8(27), KIF19(27), HOXA4(27), LILRB3(27), RPA3(26), PRKAA1(26), RBAK(26), LRRC2(26), SHMT1(26), ZNF425(26), LINC00672(26), H4C12(26), HOXC8(26), KCNK17(26), DSTYK(26), PEA15(26), ALMS1P1(26), PMCHL2(26), SERHL(26), PDGFA(26), POU5F1(26), AC105052.1(26), PYY2(26), SPON1(26), NCOA4(26), RPAP3(25), TMEM40(25), L3MBTL2(25), CPD(25), TWIST1(25), SMU1(25), MYBPH(25), MBD6(25), UBQLNL(25), SPATA31E1(25), NUDT19(25), PRB4(25), H3C10(25), RAB2A(25), MICU1(25), SAYSD1(25), SMYD1(25), LGR6(25), SHROOM3(25), BIN3(25), FAM167A(25), POLL(25), ANKK1(25), PTP4A2(25), GAGE2A(25), MAP3K3(25), ZNF525(25), CKLF-CMTM1(25), ANKRD20A1(25), ADRA2B(25), EVC(24), PASK(24), FLVCR2(24), EMC4(24), SPATA6(24), MOB3A(24), IRS2(24), AGPAT1(24), CEACAM1(24), BAG1(24), CDK8(24), SUOX(24), CTF1(24), PRKCD(24), TCP10L2(24), SFN(24), FAM227A(24), MUC6(24), CASP4(24), C2CD4A(24), OR5V1(24), FCGR2C(24), PRECSIT(24), AL049839.2(24), PRY(23), OR56A1(23), MCM4(23), LYZL1(23), MGARP(23), PTDSS1(23), SYNC(23), DDR2(23), SPATA18(23), OVOL1(23), MBOAT4(23), CPSF4L(23), TUSC1(23), B3GNT9(23), TCF15(23), OBSCN(23), SMG1(23), AQP5(23), POC1A(23), LAMB2(23), DDX60L(23), UBA52(23), TSPAN6(22), EXTL3(22), BICD1(22), ZDHHC19(22), FBXL21P(22), CLCF1(22), ZC3H11A(22), TRIB3(22), UBE2R2(22), CEMIP2(22), CHMP4C(22), C15orf39(22), IFNB1(22), H2AC6(22), ZMYM1(22), C1orf185(22), WNT16(21), PFDN1(21), GADD45A(21), NUSAP1(21), SPATA22(21), LRSAM1(21), CA5B(21), TAS1R1(21), FMR1NB(21), DHRS4L2(21), MTRNR2L11(21), HDGFL1(21), ACADL(21), AKT3(21), ELF5(21), ACTL6A(21), TMEM14B(21), ESR2(21), SCD5(21), KLF10(21), TTC39C(21), CXCL8(21), CETN1(21), SHPK(21), MIR1915HG(21), ITPRIPL2(21), FMO9P(21), LYPLA1(20), RGS16(20), TMEM145(20), AC093323.1(20), LY6G6F(20), CROT(20), GSK3B(20), PACSIN2(20), NFKBIA(20), CPQ(20), TTC12(20), PTPDC1(20), ZNF761(20), ANGPTL4(20), LRRC75A(20), TSKU(20), VSIG10L(20), CARD16(20), AC092647.5(20), CX3CL1(19), GTF3C1(19), GCNT3(19), NOL3(19), SLAMF6(19), SPRY1(19), VWC2L(19), FAM166B(19), CREBBP(19), IL5RA(19), PPIF(19), TNNC1(19), TCF21(19), CCDC70(19), SOX9(19), USP29(19), OR8K1(19), C18orf54(19), XAGE3(19), DPP4(19), LPAL2(19), KCNN2(18), FETUB(18), RAB36(18), SAA2(18), CCNA2(18), CDC123(18), ARSK(18), CCDC171(18), TC2N(18), SEMA4C(18), C11orf86(18), H2BC13(18), MAGEE2(18), FAM155A(18), KRTAP1-5(18), AC011479.1(18), PVALB(18), RAD51AP1(18), CTH(18), PGF(18), CUTC(18), DUT(18), RNF138(18), BARD1(18), TMEM236(18), SPRY1(18), HMGB2(18), KNTC1(18), GOLGA8R(18), UROS(18), IQANK1(18), RXRB(18), LINC02693(18), ANKRD20A3P(18), MYOM3(17), EIF4ENIF1(17), KRT39(17), HSBP1(17), TMEM225B(17), KLF14(17), RHBDF1(17), MCM10(17), SDF4(17), UBE2D4(17), SMARCA2(17), DNM1L(17), RIOK3(17), MLX(17), DROSHA(17), TP53I3(17), RBPJL(17), RAC2(17), AANAT(17), PODNL1(17), TLR4(17), RPTOR(17), HUNK(17), TEX261(17), ADAM12(17), MMS19(17), RPP25L(17), KATNAL2(17), FNDC9(17), LINC02870(17), SH3BGR(17), FAM221A(17), LCE1C(17), SETSIP(17), H3C6(17), NUDT18(17), FP565260.2(17), SOBP(16), TANC1(16), CRNN(16), LRRIQ3(16), OR2B2(16), SNTG2(16), MFSD2B(16), LGALS16(16), AL691442.1(16), RBL1(16), NOS1(16), ACTR1B(16), CRIPT(16), METTL8(16), RHOF(16), GNAL(16), PCDH15(16), BIRC8(16), TASOR(16), C5orf63(16), GLB1(16), GNG5(16), BGN(16), HBE1(16), TM6SF2(16), PRSS41(16), KRTAP12-2(16), LINC00205(16), AC006538.2(16), AC004223.3(16), DACH1(16), SND1-IT1(16), DNASE1L1(15), SIDT1(15), GRB14(15), RNF146(15), RGSL1(15), EAPP(15), LOXL2(15), ARMC10(15), RSPH9(15), RPE(15), UGT1A1(15), SMARCA1(15), RPA3(15), TEC(15), PARP9(15), PFKL(15), ABCA12(15), SLC30A2(15), USP24(15), BMPER(15), CALB2(15), CSDC2(15), LMNB2(15), VSIG10(15), WSCD1(15), HOATZ(15), SH2D1A(15), EFCAB10(15), OR7A5(15), UGT2B17(15), HCG9(15), NEXN-AS1(15), LINC02203(15), EFHC1(14), TSFM(14), ADM2(14), SLC6A8(14), ADAM19(14), GPR55(14), DPEP3(14), HTR4(14), OTOGL(14), SERF1A(14), ROR1(14), EEF1AKMT2(14), NOL7(14), SELE(14), SULT2B1(14), TUBA1B(14), BTN2A2(14), CGREF1(14), CCDC175(14), CIB4(14), RER1(14), KLHDC8A(14), FABP5(14), SERPINB8(14), RCCD1(14), XPO6(14), PPARA(14), ZNF70(14), HDAC2(14), STUM(14), BTBD19(14), MT1HL1(14), SMIM20(14), PABPC4L(14), FOXD4L6(14), AZGP1(13), NFATC3(13), TMPRSS11E(13), ADD1(13), ZNF436(13), CHURC1-FNTB(13), AFG1L(13), PAX3(13), LRRC4C(13), IFNGR2(13), PPM1M(13), UTS2R(13), TSHZ2(13), ZNF267(13), ZNF749(13), SCGB1C1(13), ARMCX4(13), SYT3(13), LINC00337(13), IGF1(13), TDP1(13), GNAS(13), DYRK1B(13), CYP3A5(13), SULT1E1(13), SEMA5A(13), ARMCX5(13), DIAPH1(13), ASCC1(13), AKAP4(13), MSRB2(13), NNMT(13), P2RY6(13), DIRC1(13), B3GNT5(13), MEX3D(13), NKX2-5(13), PIM3(13), ZNF805(13), GOLGA8O(13), PCDHA13(13), CD8B2(13), UBE2Q2L(13), ZNF516-DT(13), FO681492.1(13), MYH7(12), PDYN(12), ACBD5(12), TAAR6(12), SETD9(12), RTP3(12), TMEM102(12), CALHM3(12), SIX6(12), BLOC1S2(12), AC018630.4(12), KDM5D(12), BEX4(12), BST1(12), LOXL3(12), MXI1(12), IKZF4(12), TNFSF14(12), PDE11A(12), EIF2AK4(12), C5AR2(12), ARMC9(12), REM2(12), ABRACL(12), PRDM14(12), ARFGAP2(12), CCNB2(12), MSX1(12), NDUFS4(12), ULK4(12), UBE2E1(12), GNB2(12), HSPA6(12), OR6C4(12), PRR27(12), PLA2G2A(12), DAPK1(12), ELANE(12), KIR2DS4(12), CFL1P1(12), HOXA10(12), DCP1A(12), CCL3L3(12), ANOS1(11), BEST2(11), TUSC3(11), ETV2(11), CSF3(11), WFDC3(11), PEDS1-UBE2V1(11), ADAM20(11), AIG1(11), DHRS13(11), NXPH3(11), GPRIN3(11), KIAA0408(11), SPDYC(11), HIGD1C(11), AC012531.2(11), BIRC5(11), TBX15(11), PABPC1L(11), TUBB4A(11), CABP5(11), TMEM248(11), STK11(11), RPAP2(11), PMS2P5(11), FLNC(11), POSTN(11), OCM2(11), SP110(11), ALDOB(11), CCL21(11), PNMT(11), RGS16(11), PSPH(11), EDNRA(11), RAB28(11), CBS(11), OSR2(11), MBOAT1(11), C12orf54(11), TMEM252(11), ANKRD45(11), OLFML2A(11), KANK2(11), PIGN(11), MYH6(11), TUBA3C(11), SULT1C2(11), NPIPA8(11), TWIST2(11), VSIG8(11), NME2(11), AC069368.1(11), UHRF1(11), H3C7(11), EIPR1(10), P2RY10(10), ABCD1(10), ZNF35(10), MANEA(10), C12orf66(10), OR4N5(10), ZDHHC18(10), ANKUB1(10), RHOBTB2(10), RGPD5(10), MTFR1(10), F11(10), MOSPD1(10), DLX5(10), P2RX1(10), DBX1(10), ITGB6(10), TXNDC9(10), PROC(10), RARRES1(10), IFI27L2(10), WWP1(10), DYRK2(10), YWHAH(10), CEP85(10), EDEM1(10), CHST4(10), RPS27A(10), CDKN2B(10), CCDC81(10), PFKM(10), LRRK1(10), GART(10), NTNG1(10), OSGIN2(10), PBK(10), GPR82(10), MLLT3(10), RAD23A(10), RNF227(10), SPDYE16(10), CARMIL3(10), TMEM201(10), CYS1(10), DCDC2C(10), AL672142.1(10), AC137834.1(10), ITGB3(10), SMIM32(10), RNF128(9), UPB1(9), LUZP4(9), PAPPA2(9), PRLHR(9), OR7C1(9), FGL2(9), ADAMTS19(9), CFAP161(9), RWDD2B(9), TSPAN7(9), NPR2(9), SYTL3(9), KLHL30(9), BNC1(9), TMEM107(9), SPEM2(9), PLPP4(9), PCDHA4(9), CGB8(9), CPTP(9), HGF(9), FOXC1(9), ATP2B4(9), LNX1(9), GANAB(9), IRAK3(9), TNNC2(9), KCNN4(9), ERCC2(9), UST(9), MORC1(9), MTIF3(9), FOSB(9), PATJ(9), TMEM106C(9), NT5E(9), PDX1(9), DYRK3(9), KDM6A(9), TNKS1BP1(9), P4HA3(9), ADAM33(9), FANCC(9), C16orf86(9), AIRE(9), RHO(9), PLK1(9), NSG2(9), LRRN3(9), ADCY6(9), FAM9B(9), MRFAP1L1(9), SH2D7(9), ARMCX2(9), USP18(9), UBALD2(9), KRTAP15-1(9), HSH2D(9), ZNF442(9), C6orf89(9), AGPAT1(9), C7orf66(9), KLRC2(9), FER1L6(9), OR1J4(9), PCDHGA8(9), AC140504.1(9), PRSS46P(9), DGKK(9), H4C4(9), COL9A3(8), NCR2(8), P2RX3(8), P3H1(8), FLG2(8), NFKBIZ(8), SYTL5(8), TCHH(8), OR5B2(8), SLC2A14(8), OR10K1(8), CSPG4(8), RBM4B(8), PRG2(8), DCAF12L2(8), TRIM39-RPP21(8), ASIC5(8), HDAC4(8), TXK(8), TIGAR(8), TTC28(8), GMPR2(8), PHEX(8), LIMK1(8), IL2(8), NT5C1A(8), SERP1(8), H1-3(8), GALNT8(8), TUBGCP2(8), TUBG1(8), RAB25(8), ITGA7(8), GNS(8), MED4(8), DMRT1(8), PAQR5(8), SLC38A4(8), PTPRQ(8), NEDD1(8), EFNA3(8), OSMR(8), INCENP(8), MAGED4(8), C9orf85(8), ACE(8), SPIC(8), CCT2(8), BMP1(8), TSPY2(8), THBS3(8), PDGFD(8), MTBP(8), MUCL1(8), ZNF77(8), PGBD4(8), HSF1(8), PLCD1(8), CHP1(8), TMEM120A(8), LEKR1(8), ADH4(8), CRLF2(8), TSGA13(8), TRIM64C(8), PRB4(8), DSCR10(8), AL138752.2(8), MTRNR2L1(8), KLRF2(8), COL23A1(7), DZANK1(7), ANGPT2(7), GNLY(7), SIX1(7), ATIC(7), KLHL35(7), BRINP3(7), FYCO1(7), PRAP1(7), PKD1L2(7), NPNT(7), SHCBP1(7), GPR39(7), SSX7(7), SERTAD1(7), ZFP2(7), BTBD17(7), EEF1DP3(7), H2BC10(7), ASB4(7), ZBTB32(7), SIKE1(7), HIPK2(7), PRKCQ(7), RPS6KA6(7), GLI2(7), SEPHS1(7), CFAP61(7), DLL3(7), GGT5(7), RPL3(7), NELFCD(7), CUBN(7), RGS9(7), CCDC34(7), BMP5(7), PDE10A(7), STAT1(7), RAB14(7), UTP20(7), AGO2(7), ALOX5AP(7), EPSTI1(7), SCYL2(7), BRIP1(7), GALNT5(7), TFAP2A(7), SH3GL1(7), ITGA10(7), OAZ3(7), SLC20A1(7), GADL1(7), RBPMS(7), RUNX1(7), KIAA1522(7), EIF5A2(7), CASP3(7), FRMD7(7), C12orf50(7), CYB5A(7), IFTAP(7), SMAD3(7), CDH2(7), ATOH1(7), MYD88(7), VANGL1(7), PPP1R3B(7), SAA1(7), EVX2(7), TUBB6(7), LRRN4CL(7), SPATA31E1(7), LRRC75B(7), F2(7), MRPS11(7), PRKAR1B(7), FUT4(7), S100A5(7), WDR5B(7), HMGN5(7), EFCAB2(7), GJE1(7), IFIT1B(7), MAFB(7), C6orf47(7), KRTAP29-1(7), KLLN(7), AL669918.1(7), KHDC1L(7), AL049634.2(7), AC129492.3(7), H2BC8(7), CCL4L2(7), TMSB10(6), GYG2(6), KLHL22(6), RUBCNL(6), POPDC3(6), FBLN7(6), SORCS3(6), ORAI2(6), OR51B6(6), UMODL1(6), ENSG00000228439(6), CDC27(6), DNASE1L1(6), MCOLN3(6), UBE2K(6), DIMT1(6), IFT27(6), EP300(6), CTSG(6), CDKN3(6), FGF21(6), PTN(6), NCAPG(6), GNB4(6), CCT4(6), CENPL(6), TBX4(6), NPY(6), WNK4(6), DGCR6L(6), ACE2(6), ACTN4(6), MYBPH(6), PIWIL4(6), CCDC115(6), C6orf52(6), RDX(6), HADH(6), PAPSS1(6), TMTC3(6), ADAM21(6), FBN3(6), TUFT1(6), RALB(6), AFF3(6), ADAMTS16(6), SKP2(6), RBAK(6), GPR174(6), SLC25A37(6), ADD3(6), PPP1R1C(6), ZNF837(6), RGPD3(6), SVOPL(6), ADCY9(6), SELENON(6), OTUD4(6), DLC1(6), CATSPER2(6), STAT3(6), PDCD6IP(6), TMEM196(6), TAS1R1(6), SPATA3(6), PLK3(6), TMEM81(6), CTBP2(6), OR2T12(6), GATA2(6), OAZ2(6), SLC2A4(6), BRF1(6), STK40(6), MDM4(6), KIFBP(6), INSYN1(6), PPP1CB(6), NUDT19(6), SBK3(6), DICER1-AS1(6), ZNF295-AS1(6), CASTOR1(6), STMP1(6), LY6G6D(6), AL355102.2(6), C19orf84(6), AD000671.2(6), AC011530.1(6), CSAG3(6), AC091959.1(6), H2AC8(6), CABIN1(5), SNU13(5), CEP152(5), SUPT6H(5), ARHGEF17(5), PPFIBP1(5), ULBP1(5), RSAD2(5), UBAC2(5), MFSD9(5), SHROOM3(5), CXCL1(5), NELL1(5), GBX2(5), NANP(5), KCNS3(5), GPR171(5), TMTC2(5), SAMD11(5), SLC5A3(5), RBP3(5), TFPI(5), PROM1(5), ST7L(5), DSG2(5), NDC1(5), ACSM2B(5), SCARB1(5), FAM118A(5), SEL1L2(5), SAMHD1(5), SNAPC2(5), APOBEC1(5), SLC35A3(5), RNF146(5), CCND2(5), C10orf88(5), AKR1D1(5), SLC25A16(5), DNPEP(5), FLRT1(5), OMD(5), SMO(5), CRACR2A(5), UBA1(5), LRRC9(5), WBP2(5), PIK3C2B(5), IL33(5), FHDC1(5), RHBDL3(5), CREB5(5), TMEM123(5), UBASH3B(5), RAB6B(5), RPGR(5), MRAS(5), C1QTNF7(5), CDCA7L(5), CA3(5), SUGT1(5), ACSM1(5), BDKRB2(5), RFWD3(5), SIX2(5), IL17D(5), AGR3(5), RAG2(5), OR51T1(5), SHMT1(5), ANXA2R(5), PCDHB9(5), OR56A1(5), COL18A1-AS1(5), DGCR6(5), PNMA3(5), KMT5A(5), H2BC21(5), EIF4ENIF1(5), APOBR(5), SLC36A2(5), C15orf61(5), FAM72A(5), CR1L(5), NEU4(5), LY6G6F(5), COLQ(5), C1orf167(5), ZNF630(5), LINC00242(5), H2BS1(5), ZBTB22(5), ARHGEF38(5), P3R3URF(5), EIF5AL1(5), FPGT(5), MRPL46(5), AC020636.2(5), FAM72C(5), AC067968.1(5), H4C12(5), TYW1B(5), MRC2(4), RUFY3(4), SERPIND1(4), NDRG3(4), CST9L(4), DHRS12(4), RWDD1(4), KHDRBS2(4), CA14(4), GLT8D2(4), ANAPC13(4), ARHGAP20(4), FCRL5(4), ST6GAL2(4), NIPSNAP2(4), MARVELD2(4), BSND(4), PLAAT5(4), GP2(4), SLC35E3(4), VCX2(4), NGRN(4), TMEM95(4), NAP1L3(4), ANGPTL5(4), PPP1R26(4), OR5K2(4), WNT16(4), PARP12(4), ALDH18A1(4), MAOB(4), DGCR2(4), SPEG(4), ATP12A(4), TP73(4), TTC39A(4), SMOX(4), FH(4), TTLL1(4), TOM1(4), CEP128(4), SLC35A2(4), PARD6A(4), FBXO31(4), IQCH(4), SHD(4), STEAP1B(4), SERPINE1(4), CPD(4), SIM1(4), C6orf118(4), CTBS(4), COLEC11(4), RAD23B(4), TNFRSF10B(4), TSHZ3(4), PLAU(4), CFP(4), APOL5(4), EMILIN2(4), IMPA1(4), ADAM19(4), TXN(4), WDR38(4), ALDH1B1(4), TCF19(4), MFSD13A(4), ATAD1(4), DIAPH3(4), SCAPER(4), CMTM3(4), NOL3(4), CSNK1D(4), IGSF3(4), RIT1(4), MYLK4(4), VWDE(4), IGFBP3(4), ZC3HAV1L(4), PSKH2(4), SLC5A12(4), LRRC4C(4), HSPA13(4), PPP2R2B(4), FAM122C(4), ATXN7(4), CLEC3B(4), HHIP(4), CCDC112(4), GPR85(4), ZCCHC24(4), TAF3(4), VDAC2(4), PRDX3(4), ANAPC16(4), ILK(4), YWHAB(4), OR51E2(4), RNF187(4), IL7R(4), TMEM154(4), MOB3A(4), SLFN12(4), CST9(4), DPP10(4), RMI2(4), CD151(4), FAM20C(4), ERN1(4), MPI(4), APOBEC3B(4), PLAG1(4), TSHZ2(4), GLRX5(4), LRIT3(4), VPS33B(4), C6orf201(4), HSPA14(4), TREML4(4), KRTAP10-6(4), PRELP(4), ACADSB(4), KRT39(4), RPS26(4), ZNF311(4), ZNF808(4), MAFK(4), RIPPLY2(4), NOTCH4(4), OR2J1(4), LRRC3C(4), ITSN1(4), SMIM21(4), ZBTB9(4), SEC14L6(4), NUTM2D(4), TENM3(4), CTAGE4(4), NKX1-2(4), PRR23C(4), LINC02817(4), PRSS56(4), PEDS1(4), OR2AE1(4), ANP32C(4), TNFSF12-TNFSF13(4), CCDC71L(4), PCDHGB7(4), BLOC1S5-TXNDC5(4), KLF14(4), GABRQ(4), TMEM185A(4), MICOS10-NBL1(4), BIVM-ERCC5(4), MTRNR2L11(4), AC022384.1(4), SEBOX(4), HSPB6(3), ACER3(3), ZC3HAV1(3), FRG1(3), WIPF3(3), NMI(3), CATSPERB(3), ILDR1(3), GOLGA7(3), GINS4(3), BTBD11(3), BTG3(3), PGAP3(3), DNAAF5(3), SVEP1(3), GPD1(3), ACAD9(3), CD300LB(3), NT5C1B(3), PRSS48(3), GYPE(3), KIFBP(3), PPP2R2A(3), TRIM16(3), MIA(3), OR13C5(3), ENSG00000163009(3), ARX(3), ABCC8(3), CYP24A1(3), LETMD1(3), TNS1(3), KCNN2(3), REST(3), TMPRSS11E(3), TBX5(3), CMTM6(3), MACROH2A2(3), PCDH11Y(3), CRYBB1(3), RAB36(3), REC8(3), GUCY2F(3), SUV39H1(3), PIM2(3), GATA1(3), ARL2BP(3), STK3(3), LHB(3), JAK3(3), HIBADH(3), RARRES2(3), STC2(3), REEP6(3), PRRX1(3), LRRC42(3), PHF13(3), C1orf109(3), CRYGD(3), GLRXP3(3), CNTRL(3), PIK3CA(3), SMU1(3), ACO1(3), TSFM(3), IL9R(3), MOCS1(3), CDKN1A(3), MT2A(3), HNRNPH2(3), RAP1B(3), EMC4(3), RAI2(3), TMEM254(3), LOXL2(3), CCNB1(3), FST(3), TROAP(3), SLC19A3(3), STRA6(3), UNC45A(3), ST8SIA2(3), NUDT7(3), TOB1(3), SYT14(3), RUBCN(3), ANK2(3), SHISAL2B(3), FAM217A(3), CYP39A1(3), AIG1(3), TMEM47(3), KAT14(3), OCSTAMP(3), VEGFC(3), CD226(3), SLC16A12(3), CWC27(3), TXNDC11(3), ROBO3(3), TIAM1(3), DRC1(3), TNFRSF14(3), RNF207(3), UBASH3A(3), MXRA8(3), FRZB(3), PRDM9(3), CDC20B(3), HPS6(3), CUL5(3), TMEM100(3), SCNN1G(3), BATF2(3), SEMA4C(3), MN1(3), CLIC3(3), ONECUT1(3), GUSB(3), ZNF35(3), ZPLD1(3), SERPINA6(3), ARMC10(3), LURAP1(3), CHCHD1(3), NLRP13(3), HSPB7(3), MARCHF3(3), C12orf66(3), REP15(3), KY(3), INHBC(3), DDIT3(3), UBQLNL(3), C15orf54(3), PRSS42P(3), C10orf120(3), GUSBP1(3), FAM3B(3), TOB2(3), SMYD3(3), ROR1(3), IFIT1(3), OR5D14(3), GPR141(3), DHRS4L2(3), PPP3R2(3), SHISA6(3), VN1R2(3), SUPT3H(3), TRRAP(3), SLC22A4(3), MAK16(3), TLK1(3), RPA4(3), C9orf135(3), TTC25(3), SLFN12L(3), SACM1L(3), OR2F1(3), C10orf105(3), CENPVL3(3), LINC00337(3), SLFN14(3), TEX51(3), AC244197.3(3), AL365232.1(3), LILRA6(3), MARCOL(3), TMEM158(3), ATP6V1G2-DDX39B(3), INAFM1(3), TMEM179(3), AC090527.2(3), TUBB8(3), GTSCR1(3), RNF115(3), AC010646.1(3), AC093423.3(3), TM4SF19-TCTEX1D2(3), DUSP14(3), SPATA31A7(3), H2BC3(3), CCL3(3), OR12D2(3), FUT8(2), NRDC(2), CCDC9(2), GPRC5D(2), C3orf52(2), CENPK(2), MTHFS(2), RABEPK(2), DMAC1(2), ATAT1(2), URB1(2), CHRNA6(2), RBM46(2), SLC37A1(2), SHROOM1(2), SNAPC3(2), MELK(2), UGT1A6(2), ACSM6(2), PODN(2), C3orf33(2), OR52W1(2), CHST6(2), HMCES(2), THSD4(2), NEK5(2), C6orf141(2), VEPH1(2), SZT2(2), MRPS17(2), CFH(2), HCCS(2), SKAP2(2), ABCB4(2), IFRD1(2), ARSD(2), TEAD3(2), CD4(2), MAMLD1(2), CD44(2), ARNTL2(2), IKZF2(2), POLR2B(2), RRM2B(2), PIK3CB(2), GNA15(2), COL11A1(2), SIDT1(2), DNAJC10(2), GTF3C1(2), MCCC1(2), EDN1(2), CBFA2T2(2), BPIFB2(2), TUT7(2), DZANK1(2), ICAM1(2), CLSPN(2), RFFL(2), DPYSL2(2), MYO3A(2), FKBP5(2), SIRT1(2), SH3GLB1(2), UPB1(2), ESS2(2), FKBP3(2), MYBL2(2), OPN1LW(2), AURKC(2), GSK3A(2), NOBOX(2), CDC37L1(2), KDM4C(2), ANXA10(2), HTATIP2(2), CBL(2), ASIC1(2), VDR(2), IL26(2), ULBP1(2), GLP1R(2), CCND3(2), GRB14(2), RNF19B(2), FBXO6(2), CFHR3(2), FASTKD2(2), SPACA1(2), SATB2(2), IFIT3(2), APAF1(2), ABCC11(2), TAS2R7(2), EEPD1(2), HMGB1P1(2), LYPD3(2), OR2B6(2), TRIM51(2), GOT2(2), IL1B(2), TRIP10(2), CHURC1-FNTB(2), DACH2(2), PPAT(2), ADM2(2), SGO1(2), UCK1(2), SLC6A8(2), AKAP12(2), F12(2), HHLA1(2), ANKEF1(2), CPLANE2(2), SPINK5(2), LYVE1(2), CEPT1(2), AHI1(2), CCT7(2), CHRND(2), PAX3(2), FXYD2(2), EGF(2), AEBP2(2), PCTP(2), SPATA22(2), ZCCHC2(2), PRDM16(2), BCL10(2), OSBPL10(2), NFKBIZ(2), ABHD10(2), UCN2(2), SNCA(2), MEGF10(2), MMS22L(2), OGT(2), IFNA5(2), CRB2(2), LRSAM1(2), ENDOD1(2), CCDC82(2), CAPN5(2), HMGA2(2), GRID2(2), DDX4(2), GAL3ST2(2), PDLIM3(2), CHODL(2), MOV10(2), DCK(2), ALX3(2), CLDN8(2), MAPK13(2), MMP14(2), ACAN(2), AP3S2(2), GAREM2(2), PEX10(2), PAFAH2(2), AZGP1(2), LRRC38(2), ALPL(2), FAM71A(2), SPATA18(2), SPRR3(2), FSTL1(2), PTPN13(2), LRRC2(2), GNL3(2), UBLCP1(2), TLR3(2), H2AC1(2), MIOS(2), C8orf48(2), MICALL2(2), HGSNAT(2), SSMEM1(2), CDX2(2), AVPR1A(2), DPCD(2), CRABP1(2), ELFN2(2), SGSM1(2), CCDC103(2), TBC1D21(2), TMEM145(2), OR2B2(2), XIRP1(2), VWA3B(2), KLF13(2), MAP3K2(2), ARL6IP1(2), SMAGP(2), AC093323.1(2), OR8B12(2), KCNMB3(2), HOPX(2), MROH2B(2), DNAI2(2), LGALS4(2), FAM90A1(2), OVOL1(2), CCDC63(2), C11orf86(2), RNASE8(2), HOXB2(2), TNK1(2), CD164L2(2), BASP1(2), METRNL(2), ZBTB38(2), NAP1L5(2), GPR4(2), CAVIN1(2), C18orf32(2), CCDC185(2), HMGN2P46(2), LINC00174(2), ADGRD2(2), PLD5(2), SLC47A2(2), ZFP3(2), UTS2R(2), RNF135(2), SLC9A9(2), C11orf54(2), C12orf60(2), CALHM3(2), RIPPLY3(2), TRIM61(2), MX2(2), DNAH2(2), LINC00315(2), IFNLR1(2), SP1(2), LCE5A(2), KPNA4(2), NF2(2), PRG2(2), MAGI2(2), MAGEH1(2), IGFL3(2), KRTAP24-1(2), NOXA1(2), KRT77(2), MAOA(2), BLOC1S2(2), IL1RAP(2), ARMCX4(2), SLC6A9(2), PARVA(2), PRB3(2), IRAK4(2), FKBP1C(2), WDHD1(2), STYXL2(2), PRR9(2), CD300LD(2), NEU1(2), GABBR1(2), PSG5(2), C22orf42(2), RNASE13(2), TRIM71(2), SYT3(2), CGB8(2), HAUS7(2), CEACAM16(2), MIR17HG(2), SKOR2(2), CPTP(2), C5orf66(2), ZNF717(2), NUTM2E(2), LRRC37A6P(2), HSBP1(2), RPS27AP5(2), PRAMEF6(2), SPAAR(2), B3GNT9(2), OR4A47(2), C10orf143(2), CDRT1(2), PRAMEF4(2), TMEM225B(2), OR10G2(2), MTRNR2L3(2), ASIC5(2), GPR142(2), AC009779.3(2), AC007375.2(2), MRC1(2), MUC22(2), ISY1-RAB43(2), PCDHGB3(2), IKBKE(2), RASSF5(2), ZNF850(2), AC008878.2(2), ERVV-2(2), CD24(2), CYFIP1(2), C17orf98(2), AC018630.4(2), TADA2A(2), AC036214.3(2), H3C10(2), SMIM34B(2), AC006059.2(2), AC243547.3(2), ENSG00000181013(1), HSPB6(1), PON1(1), DBF4(1), LGALS14(1), CD9(1), MRC2(1), DCN(1), EXTL3(1), ZMYND11(1), KCNG1(1), EIPR1(1), TMSB10(1), HEBP2(1), LY75(1), SLC6A16(1), EYA2(1), CALCRL(1), MEF2A(1), NEDD4(1), CLTCL1(1), SLC12A3(1), ATP6AP1(1), SDHA(1), ABCB11(1), LMAN1(1), NRDC(1), SP140(1), DNAAF6(1), PCDHB4(1), ZNF416(1), APLP2(1), COL16A1(1), USP40(1), MAST2(1), ERO1B(1), ADD1(1), SLC15A1(1), TMEM40(1), RCOR1(1), WDR76(1), KLHL22(1), SERPIND1(1), SNAP29(1), CABIN1(1), SF3A1(1), HIRA(1), ANKRD54(1), CCDC134(1), CYP2D6(1), TOMM22(1), PHF5A(1), PLEK2(1), SLC10A1(1), APEX1(1), NTSR1(1), PDYN(1), JAG1(1), CST9L(1), EPPIN(1), RAB40AL(1), SRPX2(1), RUBCNL(1), MLNR(1), SGCG(1), ZNF174(1), TUSC3(1), SGTA(1), SIGLEC5(1), KLF1(1), GAPDHS(1), ERF(1), ZC3HAV1(1), HOXA6(1), FKBP14(1), GHRHR(1), IMPDH1(1), PLOD3(1), TRIM14(1), PTGR1(1), SUSD1(1), RLN2(1), NUFIP2(1), RPS6KB1(1), RAB5C(1), EFTUD2(1), PHOX2B(1), CHIC2(1), ELF2(1), DDX25(1), CTSC(1), ARHGEF17(1), CAPRIN2(1), FOXM1(1), KHDRBS2(1), CRYBG1(1), DNPH1(1), PFDN1(1), IL5(1), PCDH12(1), TIMMDC1(1), FAM162A(1), CENPA(1), TANC1(1), LCT(1), PAPPA2(1), WDR77(1), RBBP5(1), P3H1(1), F3(1), FASLG(1), UTP25(1), RCAN3(1), RSRP1(1), CA14(1), ARG1(1), PIGZ(1), CTNNAL1(1), ESRRB(1), KLHL29(1), HOXB1(1), MAGEB4(1), LYZL1(1), A1BG(1), RGSL1(1), SLITRK3(1), LIAS(1), NXPH1(1), ACOT9(1), PLA2G12A(1), CKS2(1), WFDC3(1), GTSF1L(1), TCP11(1), SSUH2(1), CST11(1), RALY(1), BPIFB1(1), DYNC2I1(1), OR7C1(1), FGL2(1), PAICS(1), ATF4(1), LIF(1), PIMREG(1), MAP3K10(1), SLC35D2(1), TXLNGY(1), EPS8L1(1), C1QL1(1), TRAF7(1), RHOXF2(1), RFX1(1), LRRC41(1), PER2(1), POPDC3(1), ITGB4(1), GUCY2D(1), RFXAP(1), RNF128(1), GSTT2B(1), LRRIQ1(1), ATP13A3(1), PRPF38B(1), WNT2B(1), NGF(1), CYP2J2(1), UBAC2(1), ANXA1(1), CCDC146(1), CD36(1), PRPH(1), PPP1R1A(1), AFG1L(1), GPR55(1), MFSD9(1), CNMD(1), KAT7(1), RABEPK(1), YIPF3(1), TMEM63B(1), TUBB2B(1), ANXA7(1), NDST4(1), PDE5A(1), PPP3CA(1), MARCHF9(1), RNF113B(1), FAM181A(1), DUOXA1(1), DISP2(1), TLE3(1), ETFA(1), CYP11A1(1), FANCI(1), TICRR(1), MARVELD3(1), DPEP3(1), ZNF750(1), P3H4(1), ARL5C(1), ITGB3BP(1), CTTNBP2NL(1), RXRG(1), NUF2(1), SLC27A3(1), LYST(1), ST6GAL2(1), TMEFF2(1), VGLL4(1), RAB5A(1), RBMS3(1), GASK1A(1), LHFPL2(1), SDK1(1), ASB15(1), DENND2A(1), SH3KBP1(1), SYTL5(1), HDAC8(1), CHRNA6(1), PXDNL(1), CDKN2A(1), OR13C4(1), ANKRD1(1), PAMR1(1), BICD1(1), ZNF385D(1), C18orf25(1), IGSF10(1), DNAI4(1), BCL2L11(1), MERTK(1), TRIP12(1), LGI4(1), PANX3(1), SKA1(1), SETD9(1), FLACC1(1), SLC26A2(1), RASA2(1), SLA(1), GRIP1(1), FAM161B(1), GPR61(1), ART3(1), PCGF6(1), SORCS3(1), HKDC1(1), FBRS(1), ZNF618(1), WDR19(1), CFAP251(1), WASF2(1), AUTS2(1), EIF5B(1), NBL1(1), EDA(1), IFNGR2(1), SIM2(1), C1R(1), STARD9(1), NPR2(1), MPZL3(1), COL26A1(1), PGAP3(1), LARP4(1), BSND(1), SYNC(1), SLC30A7(1), DENND2D(1), B3GALNT2(1), PIGR(1), SGCB(1), PGLYRP4(1), STT3B(1), GMPS(1), FYCO1(1), RFT1(1), C1orf50(1), PGRMC2(1), F2RL2(1), F2RL1(1), HTR4(1), ARSK(1), GRIK2(1), SPATA48(1), CAMLG(1), FBXL21P(1), SPIDR(1), GPR146(1), PHAX(1), CTHRC1(1), NFIL3(1), SVEP1(1), VCP(1), ATP5F1C(1), ZNF503(1), GHITM(1), HSPA12A(1), PDZRN4(1), NELL1(1), ABTB2(1), LIPC(1), SPRED1(1), ZFYVE19(1), MSS51(1), PKD1L2(1), SEC11C(1), PLIN1(1), CCDC178(1), SUN5(1), RAB8A(1), TUBA1A(1), SLC43A2(1), CYB5D2(1), SOAT2(1), TRANK1(1), KLHL30(1), ADAM9(1), SLC16A4(1), NPNT(1), SNTB2(1), STXBP6(1), COL4A3(1), VCX3A(1), FAM110B(1), ZNF354A(1), CXCL11(1), PDILT(1), CRCT1(1), CKAP2L(1), CNBP(1), PCDH7(1), FOXD4(1), VGLL2(1), USP50(1), OR10A4(1), PLAC1(1), ESCO2(1), NHLH1(1), SRGAP2C(1), SHLD1(1), TEX37(1), NME6(1), CXCR6(1), SNTG2(1), TMCC1(1), DCP2(1), KRT2(1), ZNF680(1), PARP15(1), SLC2A14(1), TNFRSF10D(1), SUSD5(1), AC013489.1(1), RBM4B(1), KLHL15(1), CHRNA9(1), VWC2L(1), TVP23C(1), GOLGA8A(1), ZNF25(1), PPP2R2D(1), OR52W1(1), RTTN(1), ZNF135(1), WDR25(1), FMR1NB(1), DEFB104B(1), DEAF1(1), SPACA4(1), UMODL1(1), FLII(1), HTR3C(1), PRSS36(1), TMEM151B(1), PRM3(1), TNP2(1), DNAJC22(1), PARP10(1), ZNF552(1), LDLRAD3(1), ZFPM1(1), MRGPRX4(1), ABCA13(1), WFDC11(1), TDRP(1), RRH(1), MCFD2(1), ZNF594(1), PPA1(1), ZNF443(1), OXTR(1), ST20(1), LRRC57(1), TLCD5(1), LINC00301(1), SNRPE(1), TMEM30B(1), KBTBD3(1), NXPH3(1), ANXA2(1), NGRN(1), TMEM95(1), ODF3L1(1), CNOT10(1), ZNF662(1), IGSF5(1), ANKRD20A2P(1), GABRR3(1), CHST6(1), FAM9A(1), TMEM89(1), SERHL2(1), KLHL25(1), TTC32(1), SIX6(1), OR4N5(1), LRRC19(1), SMIM10(1), AQP12A(1), FLRT2(1), KIAA0825(1), ARL15(1), OR7A17(1), CLDN24(1), NPAP1(1), IRS2(1), PLK5(1), PPP1CC(1), CD300E(1), BCR(1), ERCC6L(1), ZDHHC17(1), PTRH1(1), MYMK(1), SAMD11(1), AMTN(1), DNAJB13(1), FANCA(1), PALM3(1), CLCN1(1), RNF133(1), MAGEB5(1), ZBED6CL(1), PRSS48(1), PLAC9(1), ZNF600(1), OR10J1(1), H2AC7(1), LAMB3(1), EOLA2(1), MAGEA6(1), ZSCAN5B(1), C6orf141(1), VEPH1(1), BCO2(1), NMB(1), FAM114A1(1), RPE(1), SCGB1D4(1), OR8G1(1), KIF13B(1), ZNF823(1), MBP(1), GOLGA6L9(1), TFDP1(1), SZT2(1), PEG3(1), SMOC1(1), ZFP2(1), FAM229B(1), SPANXA2(1), EFCAB7(1), ZDHHC18(1), RNF5(1), FKBPL(1), BTBD17(1), FAM155A(1), PRAMEF17(1), MICB(1), ZNF468(1), FBXO48(1), FBXO47(1), PCDHA1(1), ADGRG1(1), MFSD2B(1), CAPN14(1), IFI30(1), KRTAP1-5(1), PSMB11(1), GOLGA2P7(1), PVALEF(1), NOL7(1), C12orf77(1), ARL17B(1), EEF1DP3(1), GK3P(1), ANKRD66(1), AC011005.1(1), ZNF826P(1), OR5K2(1), PAGE2(1), CT47B1(1), STRIT1(1), KIR3DL2(1), TMEM141(1), TRIM39-RPP21(1), ABHD14A(1), AC079594.1(1), PRODH2(1), AL691442.1(1), MAGEL2(1), CCDC179(1), AC068775.1(1), ZNF271P(1), ZBED6(1), AC025165.3(1), AP001781.2(1), AC008575.1(1), TVP23C-CDRT4(1), AC068234.1(1), SPDYE6(1), XKR7(1), EPPK1(1), FIGNL2(1), AL121753.1(1), OTUD7B(1), RBP3(1), TIMM23(1), CFAP298-TCP10L(1), AC093227.2(1), AC011479.1(1), IKBKG(1), ERVV-1(1), COMMD3-BMI1(1), AL603832.3(1), MUSTN1(1), PCDHB16(1), C2orf15(1), AC012531.2(1), AC012531.3(1), AL136531.2(1), CCL23(1), TBC1D3B(1), MLLT6(1), CCL4(1), H3C1(1), RAB7B(1), H2BC10(1), AL807752.6(1), C8orf87(1)

5.4 Best C-index test in all runs

Best Elastic Net model (C-Index test)

[INFO] Coefs. list

[1] “ABCA12, ABCC3, AC010255.2, AC011455.2, AC068234.1, AC093423.3, ACCSL, ACE2, ACSM4, ADAMTS3, AL672142.1, APOBEC3C, APOBR, AQP7, ARAP3, ARHGAP12, ARL14EPL, ARL3, ARL9, ARNTL, BMP5, CALN1, CCDC152, CCDC87, CCN4, CD101, CDC25A, CDNF, CENPVL1, CEP112, CHI3L1, CIART, CLIC1, CMYA5, COL22A1, COX15, CRTAC1, CXCL12, CYB5A, DCBLD1, DESI1, DOK5, DSG3, DZIP1L, EEPD1, EFHB, EMILIN3, EMP3, EVX2, EYA4, FBXO39, FHDC1, FNDC7, FOXN1, FREM2, FSBP, FTMT, GALNT14, GALNT16, GALNT18, GALNT4, GAS1, GAS2L2, GDF15, GNL1, GPR1, GPR139, GPR15, GPR156, GRPR, H1-6, H2BC12, H2BC14, H2BC5, HDDC2, HORMAD2, HOXD12, HSPB1, IGF2BP2, IGFBP2, IGFBP5, IGSF10, IL17RC, IL1F10, IQGAP2, ITPRID2, KIF4A, KLF17, KLHL9, KLK15, KRT15, KRTAP5-6, LAX1, LCE5A, LPIN3, LRRK2, LYPD6, MAGEA3, MAGEA6, MAP3K1, MARCHF5, MGME1, MKX, MLLT3, MPI, MRFAP1L1, MROH2B, MSN, MYBL1, NAB2, NUAK2, OR4M2, OTOS, PBX3, PER3, PGM1, PLAT, PLEKHA2, PLEKHA4, POGLUT3, POMC, PRKG2, PRSS56, PTGFRN, RAB42, RAD18, RFX1, RGR, RIN1, RNASE12, RNF212, RPP30, RYR3, SAA1, SAR1A, SEL1L3, SEMA4G, SFRP2, SGCD, SHISA5, SHISAL2A, SKI, SLC18A1, SLC25A43, SLC25A45, SLC35G1, SLITRK5, SMC4, SMS, SPN, SRY, STAP1, STEAP3, SULF2, TAGLN2, TECTB, TFPI, TGIF1, TGM4, TMEM61, TMPRSS11D, TNFRSF12A, TP73, TPGS2, TRIM61, TXN2, UNG, USP4, VAV3, VN1R4, VWC2, WEE1, ZNF648, ZNF679, ZYG11A”

Test set

Full set

Best Hub model (C-Index test)

[INFO] Coefs. list

[1] “ABCC3, AC005837.2, AC245748.1, ACACB, ACTG1, ACTG2, ACTL7B, ACTL9, ACTR1A, ACTRT2, ADCY10, ADCY2, ADCY3, AL355916.3, ALB, APPL1, ARL4C, ARNTL, BCL6, BMP2, BMP4, CABP5, CAD, CALB1, CALM2, CALN1, CCL19, CD8A, CDK1, CDK16, CDK17, CDK2, CDK3, CDK4, CDK5, CDK6, CDY2B, CENPVL1, CREB1, CSNK1E, CYB5A, DIRAS3, DMD, DNAH8, DOK5, DUSP21, DUSP29, EFCAB3, ELAVL1, EPHA2, EPHB3, EPM2A, ERBB2, ERBB3, EVX2, FAU, FGF7, FGFR2, FGFR4, FLG, FLT1, FOXB1, FOXB2, FOXK1, G6PD, GAK, GEM, GNAT1, GPR15, GRB2, H2AB2, H2AX, H2BC5, H3C4, HDAC1, HSPA5, HSPA9, HSPB1, IGSF10, IHH, INSRR, ISG15, JUN, KLF10, KLF16, KLK15, LATS2, LCE5A, LEP, LIMK1, LRGUK, LRRK2, MAP2K5, MAP3K1, MAP3K19, MAP3K20, MAPK12, MAPK15, MAPK3, MAPK4, MET, MMP7, MUSK, MYB, MYBL1, MYO5B, NEDD8, NME1-NME2, NOTCH1, OAS1, OASL, OR4S1, OSR2, PAX5, PCSK1, PDLIM5, PIM1, POMC, POTEI, PPARG, PPP3R2, PRDM10, PRKG1, PRKG2, PRKX, PWP2, RAC1, RAC3, RALA, RAP2C, RASL10A, REL, REM1, RFX1, RGPD8, RHOA, RHOB, RHOBTB1, RHOC, RHOU, RIPK2, RNASEL, RND1, RPS6KA2, RPS6KA3, SDHC, SERPINE1, SIN3B, SLC17A5, SLC5A5, SNAI2, SP7, SRY, TBP, TFRC, TIE1, TMTC1, TNF, TNS3, TOP2A, TP53, TSPO, TTC24, TUBB1, TXN2, TYRO3, UBB, UBC, UBD, UBL4A, WEE1, WNT2B, WT1, YWHAZ, ZNF311, ZNF630, ZNF648, ZNF716”

Test set

Full set

Best Orphan model (C-Index test)

[INFO] Coefs. list

[1] “APOBEC3C, ARL3, C11orf21, CCDC152, CCDC182, CCDC87, CCN4, CD101, CENPVL1, CEP112, CIART, CMYA5, CRTAC1, CYTOR, DCBLD2, DENND10, DESI1, DRAXIN, DZIP1L, EMILIN3, EMP3, FAM133A, FBXO39, FBXW4, FNDC3B, FNDC7, FRA10AC1, GJC1, GPR1, GPR156, H3C8, HDDC2, ITPRID2, LYPD6, METTL7B, MGME1, PADI1, PLEKHA2, PTGFRN, RAB42, RNASE12, RYR3, SH2D4A, SHISAL2A, SLC25A43, SLC25A45, SLITRK5, SWAP70, TEX26, VWC2, WT1-AS, ZNF474”

Test set

Full set

5.5 Best Log-rank test in all runs

Best Elastic net (Log-rank test)

[INFO] Coefs. list

[1] “ABCC3, ABLIM3, AC010255.2, AC010531.1, AC093423.3, ACE2, ACSM4, ADGRE5, AKAP14, AL672142.1, ALG6, ANGPT4, ANGPTL6, APOBEC3C, ARHGAP11A, ARHGAP12, ARL14EPL, ARL3, ARL9, ARNTL, ASPM, BANK1, BMPR1A, C11orf21, C17orf77, CABP4, CALN1, CCDC152, CCDC87, CCN4, CD101, CDC25A, CEACAM1, CENPF, CENPN, CENPVL1, CENPVL3, CFAP157, CFAP251, CIART, CMYA5, COX15, CRACR2A, CRTAC1, DCBLD1, DCDC2, DES, DESI1, DNAH11, DOK5, DPP4, DZIP1L, EEF1AKMT3, EFCAB10, EFNB1, EN1, ERBB2, EVX2, EYA4, FAM166C, FAM204A, FANCB, FHDC1, FNDC7, FOLR1, FOXB1, FSBP, FTMT, GALNT18, GDF10, GDF15, GGH, GNL1, GPR1, GPR15, GPR156, GRIN3A, GSG1L, H1-2, H1-6, H2BC12, H2BC17, H2BC21, H2BC5, H3C8, HAUS7, HDDC2, HORMAD2, HOXC4, HSPB1, IGF2BP2, IGF2BP3, IGFBP2, IGFBP5, IGSF10, IL17RC, IL22RA1, IQGAP2, ITPRID2, KCTD14, KIF4A, KLHL9, KLK15, KRTAP5-6, LAX1, LCE5A, LPIN3, LRRK2, LSP1, LYPD6, MAP3K1, MARCHF5, MARCHF9, MFNG, MGME1, MKX, MLLT3, MN1, MORN4, MROH2B, MXI1, NDN, NRG3, NUAK2, NUGGC, OCIAD2, OR4M2, OR51Q1, OTOS, OTP, PADI1, PBX3, PER3, PHETA2, PLAAT2, PLAT, PLEKHA2, PTCRA, PTGFRN, RAB42, RAD18, RAD54B, RFX1, RGR, RIN1, RNASE12, RPP30, RYR3, SAA1, SAR1A, SEMA4G, SFRP2, SH2D4A, SHISA5, SHISAL2A, SKI, SLC19A3, SLC25A43, SLC25A45, SLITRK5, SMC4, SPN, SRY, STAP1, SUFU, TEX26, TGM4, TPGS2, TPX2, TRAT1, TREX2, TRIM6, TSTD1, TTYH3, UGT1A9, VWC2, WEE1, ZNF474, ZNF648”

Test set

Full set

Best Hub model (Log-rank test)

[INFO] Coefs. list

[1] “AC005837.2, ACTBL2, ACTL10, ACTL7B, ACTL9, ACTR10, ACTR1A, ADCY2, ADCY3, AL033529.1, AL355916.3, ALB, ARL4C, BMP4, CA2, CAD, CALB1, CALML3, CAPN8, CAT, CDK1, CDK16, CDK17, CDK2, CDK3, CDK4, CXCL12, DNAH8, DOK5, ERBB2, ERBB3, ERN2, ESR2, FLT1, FOXB2, GAPDH, GRB2, H2BC5, HDAC1, HSPA5, HSPB1, IFNB1, INS, JUN, LCE5A, LCK, LIMK1, LRRK2, MAP2K5, MAP3K1, MAPK1, MAPK14, MAPK4, MET, MLLT3, MUSK, MYBL1, MYC, MYH14, MYOD1, NEDD8, OAS1, OAS3, PDGFRB, PDLIM5, PIM1, POMC, POTEE, POTEI, PPP3R2, PRDM10, PRKACA, PRKG2, PTEN, PTPDC1, RAC3, RASL10A, REL, RGPD8, RHOA, RHOB, RHOC, RIPK4, RND3, RPS6KA3, SDHC, SRY, TIE1, TP53, TRIB1, TSPO, TUBB3, TYRO3, UBB, UBC, UBL4A, UTY, WEE1, ZNF648, ZNF679, ZNF716”

Test set

Full set

Best Orphan model (Log-rank test)

[INFO] Coefs. list

[1] “AADACL4, ABLIM3, AC005832.4, AC093423.3, ACE2, ACSM4, ADAMTS12, ADAMTS3, ADRA2B, AFAP1L2, AL354761.1, ANGPT4, ANGPTL2, ANKRD20A1, APOBEC3C, ARHGAP12, ARL3, BASP1-AS1, BDKRB2, BEND2, C10orf55, C11orf21, C17orf77, C1orf112, C2orf91, C6orf58, C8orf88, CBFB, CCDC152, CCDC87, CCN4, CD101, CENPVL1, CENPVL3, CEP112, CHIC2, CHST15, CIART, CLDN23, COL28A1, COLGALT1, CRACR2A, CRTAC1, CT62, CUEDC2, CYTOR, DBP, DCBLD1, DENND10, DOK5, DRAXIN, DZIP1L, EEF1AKMT3, EEPD1, EMILIN3, EMP3, ENOX2, ENSG00000241978, ENSG00000278500, ERVK3-1, FAM204A, FANCB, FBXO39, FBXO4, FMO9P, FNDC10, FNDC3B, GAGE12H, GALNT14, GALNT18, GALNT7, GAS1, GAS2L3, GDF10, GIPC3, GJC1, GOLGA6D, GPR1, GPR139, GPR15, GPR156, GRPR, H2BC14, H3C7, H3C8, H3Y2, HAUS7, IGF2BP2, IL17RC, INO80B-WBP1, ITPRID2, KLHL9, KLK15, KRTAP19-4, KRTAP5-6, LCE1C, LCE5A, LMO7DN, LUZP2, LYPD6, LYZL6, MAGEA3, MAGEA6, MAGEB17, MAGEB5, MARCHF9, MBNL3, MDM2, METTL7B, MGME1, MKX, MOXD1, MRFAP1L1, NELFCD, NTN4, NUAK2, OLAH, OR4C13, OR4M2, OTOS, OTULIN, OVOL3, PADI1, PARPBP, PCDHB16, PER3, PLAAT2, PLEKHA2, PLEKHA4, PPP1R36, PRSS33, PRSS35, PRSS56, PRXL2C, PTGFRN, RAB42, RGR, RIN1, RNASE12, RNF187, RYR3, S100A16, SEMA4G, SERTAD2, SHISA5, SHISAL2A, SKI, SLC19A3, SLC25A43, SLC25A45, SLITRK5, SPATA22, SPATS2L, SSUH2, STAC, SULF2, TENT5A, TEX26, TGIF1, TGM4, TMEM237, TMEM61, TMEM87B, TMEM92, TMPRSS9, TMSB4XP8, TPGS2, TRAM1L1, TRIM56, TRPC5OS, TSPAN31, TTYH3, USP17L4, VWC2, WFIKKN2, XKRX, ZMYND8”

Test set

Full set

NULL

6 Parameters for the report

## [INFO]          balanced.sets: TRUE
## [INFO]        calc.params.old: FALSE
## [INFO]           coding.genes: TRUE
## [INFO]     degree.correlation: pearson
## [INFO]          degree.cutoff:       0.000
## [INFO]            degree.type: string
## [INFO]      degree.unweighted: TRUE
## [INFO]      handle.duplicates: keep_first
## [INFO]                   log2: TRUE
## [INFO]                n.cores:      14.000
## [INFO]          normalization: center
## [INFO]                 ntimes:    5000.000
## [INFO]                project: lgg.data.2018.10.17
## [INFO]                   seed:    1985.000
## [INFO]                 subset: Inf
## [INFO]   subtract.surv.column: (I do not know how to display this)
## [INFO]            target.vars: list(alpha = 0.1, vars = 175), list(alpha = 0.2, vars = 51), list(alpha = 0.2, vars = 101)
## [INFO]                 tissue: primary.solid.tumor
## [INFO]                  train:       0.800